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Home / Biochemicals / Small Molecules

WS 3

SKU : BHB21300373

An Activator of TRPM8 Channel

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Alomone Labs

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Mfr.No.	W-100, W-100_1 g, W-100_10 g, W-100_5 g
Description	WS 3 (#W-100) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C13H25NO.
Synonyms	Synthetic
Background	WS 3 is a synthetic, selective TRPM8 channel agonist with an EC50 value of 3.7 uM1,3.TRPM8 is a Ca2+-permeable channel, a member of the 'long' or melastatin (M) group of TRP proteins and is activated by temperatures or by cooling compounds such as icilin, menthol and eucalyptol. The TRPM8 gene is expressed and is up-regulated in prostate cancer and other malignancies. It is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons1-3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Cas Number	39711-79-0
Molecular Weight	211.34
Solubility	Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	TRPM8 channel
Activity	WS 3 is a TRPM8 channel activator (EC50 = 3.7 uM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Bodding, M. et al. (2007) Cell Calcium 42, 618. Tsumura, M. et al. (2013) PLoS One 8, 12. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300373-1	W-100_1 g	1 g	$66		Add to Cart
BHB21300373-2	W-100_10 g	10 g	$117		Add to Cart
BHB21300373-3	W-100_5 g	5 g	$85		Add to Cart

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