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Home / Biochemicals / Small Molecules

XE991

SKU : BHB21300376

A Blocker of KCNQ Channels

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Alomone Labs

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Mfr.No.	X-100, X-100_10 mg, X-100_25 mg, X-100_5 mg, X-100_50 mg
Description	XE991 (#X-100) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H20N2O.
Background	Voltage-gated K+ channels of the KCNQ family (KV7) are widely expressed in nerves and smooth muscles where their general role is to hyperpolarise the cell membrane and thereby dampen excitability1.XE991 is a potent and selective blocker of KCNQ voltage-gated K+ channels. It blocks KV7.2 + KV7.3 (KCNQ2 + KCNQ3)/M-currents (IC50 = 0.6 uM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 uM) but is less potent against KV7.1/minK channels (IC50 = 11.1 uM)1. Suppression of the M-current causes an increase in intrinsic excitability2. XE991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer's disease therapeutics2. It was demonstrated that XE991 enhances learning and memory in healthy mice3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-300 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
Cas Number	122955-42-4
Molecular Weight	376.45
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
Target	KCNQ K+ channels
Source	Synthetic
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Yeung, S.Y. and Greenwood, I.A. (2005) Br J Pharmacol. 146, 585. Zaczek, R. et al. (1998) Pharmacol. Exp. Ther. 285, 724. Fontán-Lozano, A. et al. (2009) Hippocampus 21, 22. Wang, H.S. et al. (2000) Mol. Pharmacol. 57, 1218.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300376-1	X-100_10 mg	10 mg	$151		Add to Cart
BHB21300376-2	X-100_25 mg	25 mg	$364		Add to Cart
BHB21300376-3	X-100_5 mg	5 mg	$113		Add to Cart
BHB21300376-4	X-100_50 mg	50 mg	$690		Add to Cart

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