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Home / Biochemicals / Small Molecules

XE991 dihydrochloride

SKU : BHB21300377

A Blocker of KCNQ Channels

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Alomone Labs

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Mfr.No.	X-101, X-101_10 mg, X-101_25 mg, X-101_5 mg, X-101_50 mg
Description	XE991 dihydrochloride (#X-101) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H22Cl2N2O.
Background	Voltage-gated K+ channels of the KCNQ family (KV7) are widely expressed in nerves and smooth muscles where their general role is to hyperpolarise the cell membrane and thereby dampen excitability1.XE991 is a potent and selective blocker of KCNQ voltage-gated K+ channels. It blocks KV7.2 + KV7.3 (KCNQ2 + KCNQ3)/M-currents (IC50 = 0.6 uM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 uM) but is less potent against KV7.1/minK channels (IC50 = 11.1 uM)1. Suppression of the M-current causes an increase in intrinsic excitability2. XE991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer's disease therapeutics2. It was demonstrated that XE991 enhances learning and memory in healthy mice3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-300 uM.
Reconstitution	Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.
Cas Number	122955-13-9
Molecular Weight	449.37
Solubility	Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.
Target	KCNQ K+ channels
Source	Synthetic
Activity	XE991 blocks KCNQ channels with IC50 of 0.5-10 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Yeung, S.Y. and Greenwood, I.A. (2005) Br J Pharmacol. 146, 585. Zaczek, R. et al. (1998) Pharmacol. Exp. Ther. 285, 724. Fontán-Lozano, A. et al. (2009) Hippocampus 21, 22. Wang, H.S. et al. (2000) Mol. Pharmacol. 57, 1218.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300377-1	X-101_10 mg	10 mg	$132		Add to Cart
BHB21300377-2	X-101_25 mg	25 mg	$306		Add to Cart
BHB21300377-3	X-101_5 mg	5 mg	$113		Add to Cart
BHB21300377-4	X-101_50 mg	50 mg	$595		Add to Cart

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