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Home / Biochemicals / Small Molecules

YM 90K hydrochloride

SKU : BHB21300380

A Potent Antagonist of AMPA Receptors

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Mfr.No.	Y-105, Y-105_10 mg, Y-105_25 mg, Y-105_5 mg, Y-105_50 mg
Description	YM 90K hydrochloride (#Y-105) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H8ClN5O4.
Background	YM 90K is a selective and potent AMPA receptor antagonist. YM 90K inhibits the binding of (3H) AMPA with a Ki value of 84 nM1.YM 90K has been reported to have neuroprotective effects in focal and global cerebral ischaemia models. However, high or moderate doses of YM 90K induce behavioral changes, including sedation, muscular hypotonia and ataxia. In addition, the effects of YM 90K are short-lived. In this context, YM 90K may be useful for the treatment of acute epileptic conditions such as status epilepticus. Moreover, it might prevent pathological neuronal plasticity resulting from status epilepticus, since it shows an antiepileptogenic effect and protects hippocampal neurons during kainate-induced generalized seizures.YM 90K could be clinically useful, since a low dose exhibits significant, although weak effects against kindling without detectable behavioral adverse effects2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 50 uM.
Reconstitution	10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
Cas Number	154164-30-4
Molecular Weight	309.9
Solubility	10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
Target	AMPA receptors
Source	Synthetic
Activity	YM 90K hydrochloride is a selective AMPA receptor antagonist; Ki of 84 nM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Shimizu-Sasamata, M. et al. (1996) J. Pharmacol. Exp. Ther. 276, 84. Kodama, M. et al. (1999) Eur. J. Pharmacol. 374, 11. Ohmori, J. et al. (1994) J. Med. Chem. 37, 467.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300380-1	Y-105_10 mg	10 mg	$272		Add to Cart
BHB21300380-2	Y-105_25 mg	25 mg	$561		Add to Cart
BHB21300380-3	Y-105_5 mg	5 mg	$151		Add to Cart
BHB21300380-4	Y-105_50 mg	50 mg	$1003		Add to Cart

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