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Home / Biochemicals / Small Molecules

Zacopride hydrochloride

SKU : BHB21300381

A Potent Antagonist of 5-HT3 Receptors and an Agonist of 5-HT4 Receptors

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Mfr.No.	Z-110, Z-110_10 mg, Z-110_25 mg, Z-110_5 mg, Z-110_50 mg
Description	Zacopride hydrochloride (#Z-110) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H21Cl2N3O2.
Background	Zacopride hydrochloride is a derivative of benzamide, described as a potent 5-HT3 receptor antagonist with 5-HT4 receptor agonistic properties. Zacopride is a recemic compound. Studies showed that the S(-) form has a higher binding affinity for central and peripheral 5-HT3 receptor compared to R(+) zacopride1. Ki values for 5-HT3 and 5-HT4 receptors are 0.38 nM and 373 nM respectively3.There is some evidence from animal behavioral experiments that 5-HT3 receptor antagonists may be useful as anxiolytics, antipsychotics, cognition-enhancers and anti-addictive agents. It has been reported from these models that the S(-) enantiomer is potent in animal models of psychosis whereas the R(+) enantiomer is more potent in anxiety models1.Zacopride has been shown to be an effective anti-emetic agent against the emesis induced by cytotoxins and radiation in dogs, cats, non-human primates and ferrets2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.3-300 nM.
Reconstitution	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	99617-34-2
Molecular Weight	346.25
Solubility	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3, 5-HT4 receptors
Source	Synthetic
Activity	Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-amino-N-(1-azabicyclo(2.2.2)octan-3-yl)-5-chloro-2-methoxybenzamide hydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Bill, D.J. et al. (1995) Br. J. Pharmacol. 115, 775. Meyer, L.C. et al. (2006) Am. J. Physiol. 290, R405. Nagakura, Y. et al. (1999) Pharmacol. Res. 39, 375. Cohen, M.L. et al. (1989) J. Pharmacol. Exp. Ther. 248, 197.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300381-1	Z-110_10 mg	10 mg	$134		Add to Cart
BHB21300381-2	Z-110_25 mg	25 mg	$297		Add to Cart
BHB21300381-3	Z-110_5 mg	5 mg	$98		Add to Cart
BHB21300381-4	Z-110_50 mg	50 mg	$552		Add to Cart

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