STAT3 Antibody

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SKU

BHA12902781
Dilution

WB 1:500-1:2000,IHC 1:50-1:200,IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
Applications

IF/ICC, ELISA, IHC, WB
Alternative Names

1110034C02Rik|Acute Phase Response Factor|Acute-phase response factor|ADMIO|APRF|AW109958|DNA binding protein APRF|FLJ20882|HIES|MGC16063|Signal...

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$260

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Mfr.No.

AF6294
Dilution

WB 1:500-1:2000,IHC 1:50-1:200,IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
Applications

IF/ICC, ELISA, IHC, WB

Alternative Names

1110034C02Rik|Acute Phase Response Factor|Acute-phase response factor|ADMIO|APRF|AW109958|DNA binding protein APRF|FLJ20882|HIES|MGC16063|Signal transducer and activator of transcription 3 (acute phase response factor)|Signal transducer and activator of transcription 3|STAT 3|Stat3|STAT3_HUMAN|
Categories

Primary Antibodies
Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.
Molecular Weight

Observed Mol.Wt.: 86kDa.
Predicted Mol.Wt.: 89kDa.
Specificity

STAT3 Antibody detects endogenous levels of total STAT3.
Subcellular Location

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Antigen

STAT3
Clonality

polyclonal
Immunogen

A synthesized peptide derived from human STAT3.
Reactivity

Human, Mouse, Rat

Concentration

1mg/ml
Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage Condition

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Format

Liquid

Gene Id

6774
Uniprot

P40763

Sequence

10	20	30	40	50
MAQWNQLQQL	DTRYLEQLHQ	LYSDSFPMEL	RQFLAPWIES	QDWAYAASKE
60	70	80	90	100
SHATLVFHNL	LGEIDQQYSR	FLQESNVLYQ	HNLRRIKQFL	QSRYLEKPME
110	120	130	140	150
IARIVARCLW	EESRLLQTAA	TAAQQGGQAN	HPTAAVVTEK	QQMLEQHLQD
160	170	180	190	200
VRKRVQDLEQ	KMKVVENLQD	DFDFNYKTLK	SQGDMQDLNG	NNQSVTRQKM
210	220	230	240	250
QQLEQMLTAL	DQMRRSIVSE	LAGLLSAMEY	VQKTLTDEEL	ADWKRRQQIA
260	270	280	290	300
CIGGPPNICL	DRLENWITSL	AESQLQTRQQ	IKKLEELQQK	VSYKGDPIVQ
310	320	330	340	350
HRPMLEERIV	ELFRNLMKSA	FVVERQPCMP	MHPDRPLVIK	TGVQFTTKVR
360	370	380	390	400
LLVKFPELNY	QLKIKVCIDK	DSGDVAALRG	SRKFNILGTN	TKVMNMEESN
410	420	430	440	450
NGSLSAEFKH	LTLREQRCGN	GGRANCDASL	IVTEELHLIT	FETEVYHQGL
460	470	480	490	500
KIDLETHSLP	VVVISNICQM	PNAWASILWY	NMLTNNPKNV	NFFTKPPIGT
510	520	530	540	550
WDQVAEVLSW	QFSSTTKRGL	SIEQLTTLAE	KLLGPGVNYS	GCQITWAKFC
560	570	580	590	600
KENMAGKGFS	FWVWLDNIID	LVKKYILALW	NEGYIMGFIS	KERERAILST
610	620	630	640	650
KPPGTFLLRF	SESSKEGGVT	FTWVEKDISG	KTQIQSVEPY	TKQQLNNMSF
660	670	680	690	700
AEIIMGYKIM	DATNILVSPL	VYLYPDIPKE	EAFGKYCRPE	SQEHPEADPG
710	720	730	740	750
SAAPYLKTKF	ICVTPTTCSN	TIDLPMSPRT	LDSLMQFGNN	GEGAEPSAGG
760	770
QFESLTFDME	LTSECATSPM

Manual

(pdf)
MSDS
IHC Protocol.
Western Blotting Handbook.

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STAT3 Antibody

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