JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Trichostatin A

SKU : BHB21300351

A Powerful Histone Deacetylase Inhibitor

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	T-300, T-300_0.5 mg, T-300_1 mg
Description	Trichostatin A (#T-300) is a highly pure, natural, and biologically active compound.
Molecular Formula	C17H22N2O3.
Synonyms	Natural
Background	Trichostatin A (TSA), an antifungal antibiotic derived from Streptomyces, is a potent and reversible inhibitor of histone deacetylase.1 TSA causes accumulation of highly acetylated histone molecules in mammalian cells,2 that leads to chromatin relaxation and modulation of gene transcription/expression.3TSA blocked cell cycle progression at the G1 phase in HeLa cells.4 In NIH 3T3 cells, it induced reversion of oncogenic ras-transformed cells to a normal morphology.5 TSA did not induce apoptosis in primary rat hepatocytes,6 however, it induced cell-cycle arrest and apoptosis in human hepatoma cell lines (HepG2, Huh-7).7Unlike sodium butyrate, Trichostatin A action is very specific and reversible and thus, became a widely used tool to study the consequences of histone acetylation in vitro and in vivo.TSA strongly inhibited the cellular growth of nine pancreatic adenocarcinoma cell lines. It induced up-regulation of p21 (WAF1/CIP1), cell cycle arrest at G2, and apoptosis. Therefore, TSA may have a potential utility in treatment of pancreatic cancer.8Recently, TSA was reported as a potent inhibitor of Gelatinase A, a matrix metalloproteinase implicated in metastasis,9 and it also inhibited the secretion of vascular endothelial growth factor (VEGF) from human glioblastoma cells.10 Preclinical evaluation of TSA in combination with DNA methylation inhibitors, demonstrated a synergistic anti-neoplastic effect against myeloid leukemic cells.11
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 1 uM.
Reconstitution	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	58880-19-6
Molecular Weight	302.4
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	Trichostatin A, an antifungal antibiotic, irreversibly inhibits histone deacetylase1. It could also promote apoptosis2 and in some cases even inhibits the proliferation of some cancer cells3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6- di methyl-7-oxo-2,4-heptadienamide.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to two weeks at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Tsuji, N. et al. (1976) J. Antibiot. (Tokyo). 29, 1. Yoshida, M. et al. (1990) J. Biol. Chem. 265, 17174. Yoshida, M. et al. (1995) Bioessays 17, 423. Hoshikawa, Y. et al. (1994) Exp. Cell Res. 214, 189. Futamura, M. et al. (1995) Oncogene 10, 1119. Papeleu, P. et al. (2003) J. Hepatol. 39, 374. Yamashita, Y. et al. (2003) Int. J. Cancer 103, 572. Donadelli, M. et al. (2003) Mol. Carcinog. 38, 59. Ailenberg, M. et al. (2002) Biochem. Biophys. Res. Commun. 298, 110. Sawa, H. et al. (2002) Brain Tumor Pathol. 19, 77. Shaker, S. et al. (2003) Leuk. Res. 27, 437. Yoshida, M. et al. (1990) J. Biol. Chem. 265, 17174. Yamashita, Y. et al. (2003) Int. J. Cancer 103, 572. Donadelli, M. et al. (2003) Mol. Carcinog. 38, 59.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300351-1	T-300_0.5 mg	0.2 mg	$129		Add to Cart
BHB21300351-2	T-300_1 mg	1 mg	$167		Add to Cart
BHB21300351-3	T-300_1 mg	5x1 mg	$655		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.