Mouse Anti-Human TrpC7 Monoclonal IgG1

Mfr.No.	SMC-343, SMC-343D, SMC-343D-A390, SMC-343D-A488, SMC-343D-A594, SMC-343D-ALP, SMC-343D-APC, SMC-343D-BI, SMC-343D-FITC, SMC-343D-HRP, SMC-343D-PCP, SMC-343D-RPE, SMC-343S
Immunogen Species	Human
Alternative Names	TRP7 Antibody, KNP3 Antibody, TRPM2 Antibody, transient receptor potential cation channel subfamily C member 7 Antibody
Antigen	TRPC7
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	1 ug/ml of SMC-343 was sufficient for detection of TrpC7 in 10 ug of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Mouse Anti-Human TrpC7 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide amino acids 845-862 of human TRPC7, Homo Sapiens (Human)
Immunogen Region	Synthetic peptide amino acids 845-862 of human TRPC7
Isotype	IgG1
Launch Date	2010/03/31
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q9HCX4
Accession Number	NP_065122.1
Gene Id	57113
Target	TRPC7
Clone No	N64A/36
Research Area	Ion Channels, Transient Receptor Potential (TRP) Channels, Cell Signaling, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (1). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (2).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~100kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, IHC, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP ; AM
Dilution	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Numaga T., Wakamori M., and Mori Y. (2007) Handb Exp Pharmacol. 179: 143-151. 2. Satoh S., et al. (2007) Mol Cell Biochem. 294(1-2): 205-215.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11903222-1	SMC-343D	Unconjugated	100 ug	$330	Add to Cart
BHA11903222-2	SMC-343D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11903222-3	SMC-343D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11903222-4	SMC-343D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11903222-5	SMC-343D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11903222-6	SMC-343D-APC	APC	100 ug	$382	Add to Cart
BHA11903222-7	SMC-343D-BI	Biotin	100 ug	$378	Add to Cart
BHA11903222-8	SMC-343D-FITC	FITC	100 ug	$374	Add to Cart
BHA11903222-9	SMC-343D-HRP	HRP	100 ug	$370	Add to Cart
BHA11903222-10	SMC-343D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11903222-11	SMC-343D-RPE	RPE	100 ug	$380	Add to Cart
BHA11903222-12	SMC-343S	Unconjugated	12 ug	$44	Add to Cart

TRPC7 Antibody, Clone N64A/36 - SMC-343