{"product_id":"32-carbonyl-rmc-5552-bhb21900922","title":"(32-Carbonyl)-RMC-5552","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eInhibitors\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003e(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor that inhibits mTORC1 and mTORC2 substrate phosphorylation — p-P70S6K-(T389), p-4E-BP1-(T37\/36), and p-AKT1\/2\/3-(S473) — with pIC\u003csub\u003e50\u003c\/sub\u003es of \u0026gt;9, \u0026gt;9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)\u003csup\u003e[1]\u003c\/sup\u003e. It is supplied as a white to off-white solid (C93H134N10O24, MW 1776.11) at 95.41% purity.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e2382768-55-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC93H134N10O24\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e1776.11 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e95.41%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAppearance\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eColor\u003c\/th\u003e\n\u003ctd\u003eWhite to off-white\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd\u003eNC1=C2C(C3=CC=C(OC(N)=N4)C4=C3)=NN(C2=NC=N1)CC5=CC=C(CN(CC6)C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[C@H]7[C@@H](C[C@@H](CC7)C[C@H]([C@@]8([H])OC([C@@]9([H])N(CCCC9)C(C([C@@]%10(O[C@](CC[C@H]%10C)([H])C[C@@H](\/C(C)=C\/C=C\/C=C\/[C@H](C[C@H](C([C@@H]([C@@H](\/C(C)=C\/[C@H](C(C8)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O)=O)C6=C5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003ePI3K\/Akt\/mTOR\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSolubility\u003c\/th\u003e\n\u003ctd\u003eIn Vitro: DMSO: 146.67 mg\/mL (82.58 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"5 mg","offer_id":67604885569901,"sku":"HY-134903-5MG","price":432.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":67605161443693,"sku":"HY-134903-10MG","price":696.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":67605161476461,"sku":"HY-134903-25MG","price":1380.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":67605161509229,"sku":"HY-134903-50MG","price":2220.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":67605161541997,"sku":"HY-134903-100MG","price":3600.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":67605161574765,"sku":"HY-134903-200MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":67605161607533,"sku":"HY-134903-500MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":67605161640301,"sku":"HY-134903-1MLX10MM","price":1360.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hy-134903.gif?v=1790972945","url":"https:\/\/www.ebiohippo.com\/products\/32-carbonyl-rmc-5552-bhb21900922","provider":"BioHippo","version":"1.0","type":"link"}