{"product_id":"4-9-anhydrotetrodotoxin-bhb21300355","title":"4,9-Anhydrotetrodotoxin","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)- 6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e 4,9-anhydro-TTX, Anhydroepitetrodotoxin\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 13072-89-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C11H15N3O7.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Ethanol, Methanol up to 10 mM. Less soluble directly in aqueous solution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Ethanol, Methanol up to 10 mM. Less soluble directly in aqueous solution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NaV1.6 channel\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e 4,9-Anhydrotetrodotoxin, a derivative of tetrodotoxin, is a potent blocker of the NaV1.6 channel (IC50 = 7.8 nM), selective over other TTX-sensitive sodium channels1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e 4,9-anhydro-TTX, Anhydroepitetrodotoxin\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003e4,9-Anhydrotetrodotoxin, also called 4,9-anhydro-TTX, is a derivative of tetrodotoxin, a potent neurotoxin found in a number of marine creatures including the pufferfish. 4,9-Anhydro-TTX acts as a potent and selective NaV1.6 channel blocker with an IC50 value of 7.8 nM1.4,9-Anhydrotetrodotoxin was found to block the activity of NaV1.6 channels with an efficacy of 40-160 times higher than other tetrodotoxin sensitive NaV1.x channel isoforms. The compound successfully prevents the influx of Na+ ions by blocking the pore of the NaV channel from the extracellular side of the plasma membrane2.4,9-Anhydrotetrodotoxin has become a useful pharmacological tool for the investigation and identification of the biophysical properties of NaV1.6 channels2.Voltage-gated sodium (NaV) channels are responsible for initiating action potentials in electrically excitable cells. NaV channels play an important role in human pain signaling pathways and are an important therapeutic target for the treatment of chronic pain. Mutations in NaV channels are also associated with a range of complex pathologic conditions such as epilepsy, myotonic conditions and cardiac arrhythmias3,4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"5 mcg \/ 1","offer_id":53249715536237,"sku":"T-560-5MCG-1","price":1003.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/T-560_gr.gif?v=1778544457","url":"https:\/\/www.ebiohippo.com\/products\/4-9-anhydrotetrodotoxin-bhb21300355","provider":"BioHippo","version":"1.0","type":"link"}