{"product_id":"a-192621-bhb21300027","title":"A-192621","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(2,6-diethylanilino)-2-oxoethyl]-2-(4-propoxyphenyl)pyrrolidine-3-carboxylic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 195529-54-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C33H38N2O6.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;97% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-10 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ET-B receptor\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e A-192621 is a selective antagonist of ET-B endothelin receptors, inhibiting ET-1 binding to ETA and ET-3 binding to ETB receptors with IC50 values of 4280 nM and 4.5 nM, respectively1.In vivo, A-192621 inhibits ETB-mediated dilatory and pressor responses induced by Sarafotoxin 6c (ED50 = 30 mg\/kg), and causes an elevation of arterial blood pressure and plasma ET-1 level2.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eA-192621 is a synthetic compound that acts as a selective antagonist of the endothelin B (ET-B) receptor, a member of the G-protein coupled receptor (GPCR) superfamily.In vivo efficacy studies showed that A-192621 inhibits ET-1-induced dilatory and pressor responses that are mediated by ET-B. The compound can cause an increase in arterial blood pressure and plasma ET-1 levels1,2. It inhibits ET-B receptors with an IC50 value of 4.5 nM3.ET-B receptors play an important role in regulating renal function and blood pressure and are expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia4,5.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"1 mg \/ 1","offer_id":53249705017709,"sku":"A-360-1MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"10 mg \/ 1","offer_id":53311556747629,"sku":"A-360-10MG-1","price":917.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311556780397,"sku":"A-360-25MG-1","price":1616.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311556813165,"sku":"A-360-5MG-1","price":595.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-360_gr.gif?v=1778544416","url":"https:\/\/www.ebiohippo.com\/products\/a-192621-bhb21300027","provider":"BioHippo","version":"1.0","type":"link"}