{"product_id":"a-804598-bhb21300036","title":"A-804598","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e N-Cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 1125758-85-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C19H17N5.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e P2X7 receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e A-804598 is a potent and selective, competitive and high-affinity antagonist of the purinergic P2X7 receptor, with IC50 values of around 10 nM for mouse, rat, and human receptors1-3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e N-Cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eA-804598 is a potent, competitive, and selective antagonist of the P2X7 receptor. It displays IC50 values of 10 nM, 9 nM and 11 nM for rat, mouse and human P2RX7, respectively1.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. To date, seven members of this family have been identified and shown to function as either homomeric or heteromeric combinations2. P2X7 receptors mediate the release of proinflammatory cytokines2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249707573613,"sku":"A-415-10MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311549112685,"sku":"A-415-25MG-1","price":184.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311549145453,"sku":"A-415-5MG-1","price":66.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311549178221,"sku":"A-415-50MG-1","price":333.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-415_gr.gif?v=1778544412","url":"https:\/\/www.ebiohippo.com\/products\/a-804598-bhb21300036","provider":"BioHippo","version":"1.0","type":"link"}