{"product_id":"a-889425-bhb21300006","title":"A-889425","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 1-(3-methylpyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 1072921-02-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C19H18F3N3O3S.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.5 nM - 50 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPV1 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e A-889425 blocks TRPV1 channels with an IC50 of 335 nM (rat) and 34 nM (human)1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eTRPV1 (transient receptor potential vanilloid family type 1) channels are activated and\/or modulated by noxious heat, capsaicin, protons and other endogenous agents released following tissue injury.A-889425 is a selective and competitive TRPV1 channel blocker with an IC50 of 335 nM to displace capsaicin at rat receptors, and has good penetration into the CNS1. In the somatic sensory system, receptor-selective TRPV1 antagonists, such as A-889425, attenuate mechanical hyperalgesia in models of inflammatory, osteoarthritic, and neuropathic pain2. Administration of A-889425 inhibited mechanically evoked activity of wide dynamic range (WDR) neurons in the rat spinal dorsal horn under conditions of peripheral inflammation but not in uninjured rats1.In addition to actions on the nociceptive system, several TRPV1 blockers like A-889425 have been reported to affect thermoregulation by transiently raising core body temperature following systemic administration in both animals and humans3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"1 mg \/ 1","offer_id":53249707278701,"sku":"A-195-1MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"10 mg \/ 1","offer_id":53311544885613,"sku":"A-195-10MG-1","price":354.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311544918381,"sku":"A-195-25MG-1","price":805.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311544951149,"sku":"A-195-5MG-1","price":261.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311544983917,"sku":"A-195-50MG-1","price":1474.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-195_str-1.gif?v=1778544418","url":"https:\/\/www.ebiohippo.com\/products\/a-889425-bhb21300006","provider":"BioHippo","version":"1.0","type":"link"}