{"product_id":"a-967079-bhb21300009","title":"A 967079","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (NZ)-N-[(E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene]hydroxylamine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 1170613-55-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C12H14FNO.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 100 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPA1 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e A 967079 is a blocker of TRPA1 channels and has IC50 values of 67 and 289 nM at human and rat TRPA1 receptors respectively1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eThe transient receptor potential (TRP) channel is one of the largest families of cation channels1.TRPA1 is expressed in sensory and nociceptive neurons and has a significant role in the inflammatory response. Bradykinin and histamine receptors induce TRPA1 activity. It has been found that TRPA1 deficient mice do not develop an elevated mechanical and thermal pain response following bradykinin injection. This suggests that TRPA1 has a vital role in bradykinin signaling pathways2.TRPA1 also plays a role in acute and chronic respiratory disease pathophysiology. Prolonged exposure to TRPA1 agonists such as chlorine and aldehydes can cause reactive airway dysfunction syndrome characterized by symptoms such as wheezing, cough and dyspnea. In view of this, TRPA1 is a potential target in airway anti-inflammatory research3.A 967079 is a TRPA1 blocker and has an IC50 value of 67 and 289 nM for human and rat TRPA1 receptors respectively.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249707540845,"sku":"A-225-10MG-1","price":92.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311543181677,"sku":"A-225-100MG-1","price":460.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311543214445,"sku":"A-225-25MG-1","price":151.0,"currency_code":"USD","in_stock":true},{"title":"250 mg \/ 1","offer_id":53311543247213,"sku":"A-225-250MG-1","price":916.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311543279981,"sku":"A-225-5MG-1","price":76.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311543312749,"sku":"A-225-50MG-1","price":266.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-225_gr.gif?v=1778544412","url":"https:\/\/www.ebiohippo.com\/products\/a-967079-bhb21300009","provider":"BioHippo","version":"1.0","type":"link"}