{"product_id":"aacba-hydrochloride-bhb21300035","title":"AACBA hydrochloride","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride, GSK314181A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 1101868-22-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C23H33Cl2N3O (C23H32ClN3O · HCl).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e P2X7 receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors, shown to inhibit human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively. Active in vivo on acute models of pain and inflammation1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride, GSK314181A\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eAACBA hydrochloride is a potent and selective antagonist of P2X7 receptors. It inhibits human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively1.AACBA reduces interleukin-6 release in a dose-dependent manner and prevents or reverses carrageenan-induced paw edema and mechanical hypersensitivity in acute in vivo models of pain and inflammation1.P2X receptors are a family of ion channels gated by ATP, a ubiquitous energy donor and receptor ligand in living cells. P2X receptors are widely expressed in neuronal, muscular, epithelial and immune cells and play a pivotal role in models of various pain conditions. P2X7 receptor mediates the release of proinflammatory cytokines known to have roles in inflammatory\/immune conditions and pain1,2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249705541997,"sku":"A-410-10MG-1","price":287.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311553110381,"sku":"A-410-25MG-1","price":627.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311553143149,"sku":"A-410-5MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311553175917,"sku":"A-410-50MG-1","price":969.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-410_str-2.gif?v=1778544416","url":"https:\/\/www.ebiohippo.com\/products\/aacba-hydrochloride-bhb21300035","provider":"BioHippo","version":"1.0","type":"link"}