{"product_id":"aamp-antibody-angio-associated-migratory-cell-protein-bha17135255","title":"AAMP Antibody \/ Angio associated migratory cell protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eAAMP Antibody \/ Angio associated migratory cell protein is a anti-AAMP Rabbit antibody Recombinant Rabbit Monoclonal clone 29A85 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e AAMP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29A85, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eAAMP antibody recognizes angio associated migratory cell protein, a multifunctional protein expressed in endothelial and smooth muscle cells. AAMP is involved in cell adhesion, migration, and angiogenesis. It is localized both in the cytoplasm and on the cell surface, where it interacts with heparin and integrins to regulate cell motility. AAMP contributes to vascular development and remodeling, playing an important role in processes such as wound healing and tumor angiogenesis.\u003cbr\u003e\u003cbr\u003eAAMP antibody is widely applied in vascular biology and cancer research. Studies have shown that AAMP promotes endothelial cell migration and tube formation, making it a critical factor in angiogenesis. By detecting AAMP expression, researchers can study mechanisms of vascular remodeling in normal physiology and disease. Altered levels of AAMP have been linked to pathological angiogenesis observed in tumor growth and metastasis, highlighting its potential as a therapeutic target.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, AAMP antibody detects specific protein bands, enabling quantitative comparisons across samples. In immunohistochemistry, it provides visualization of AAMP distribution in tissues, with high expression observed in vascular structures. Immunofluorescence studies highlight its subcellular localization and interactions with cytoskeletal elements. These applications make AAMP antibody a versatile reagent for cell and molecular biology.\u003cbr\u003e\u003cbr\u003eIn addition to its role in angiogenesis, AAMP contributes to immune regulation. It has been implicated in modulating lymphocyte adhesion and migration. By using AAMP antibody, researchers can investigate how AAMP facilitates immune cell trafficking and its contribution to inflammation and immune surveillance.\u003cbr\u003e\u003cbr\u003eCancer biology has further underscored the importance of AAMP. Upregulation has been linked to enhanced tumor cell motility and invasiveness. Its interactions with heparin binding proteins and integrins influence the tumor microenvironment and promote vascular support for malignant growth. Detecting AAMP with specific antibodies provides insight into how cancer cells exploit normal migratory mechanisms to drive progression.\u003cbr\u003e\u003cbr\u003eAAMP antibody provided by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=AAMP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=AAMP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=AAMP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/AAMP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=AAMP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047285776749,"sku":"FY12352","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3168664b-d533-4970-aabb-cf6e8c612c1e.jpg?v=1772019283","url":"https:\/\/www.ebiohippo.com\/products\/aamp-antibody-angio-associated-migratory-cell-protein-bha17135255","provider":"BioHippo","version":"1.0","type":"link"}