{"product_id":"aatf-antibody-apoptosis-antagonizing-transcription-factor-bha17136053","title":"AATF Antibody \/ Apoptosis-antagonizing transcription factor","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eAATF Antibody \/ Apoptosis-antagonizing transcription factor is a anti-AATF Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nucleus, Nucleolus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e AATF\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eAATF antibody detects Apoptosis-antagonizing transcription factor, a nuclear protein involved in cell cycle control, apoptosis inhibition, and transcriptional regulation. The UniProt recommended name is Apoptosis-antagonizing transcription factor (AATF). This multifunctional protein acts as a coactivator and checkpoint regulator, integrating DNA damage signaling with cell survival pathways.\u003cbr\u003e\u003cbr\u003eFunctionally, AATF antibody identifies a 560-amino-acid protein that binds transcription factors such as TP53, ATF5, and RNA polymerase II components to modulate gene expression. AATF promotes cell cycle progression by repressing pro-apoptotic genes and enhancing DNA repair. It also plays roles in ribosome biogenesis, RNA processing, and chromatin organization.\u003cbr\u003e\u003cbr\u003eThe AATF gene is located on chromosome 17q11.2 and is widely expressed in proliferating cells, especially in brain, liver, and reproductive tissues. AATF activity ensures proper coordination between transcription, cell cycle checkpoints, and apoptosis resistance during stress conditions.\u003cbr\u003e\u003cbr\u003ePathologically, overexpression of AATF is observed in several cancers, including glioblastoma and leukemia, where it enhances cell survival and tumor progression. Conversely, loss of AATF sensitizes cells to apoptosis induced by DNA damage or oxidative stress. Research using AATF antibody supports studies in transcription regulation, apoptosis, and oncogenic signaling.\u003cbr\u003e\u003cbr\u003eAATF antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect transcriptional regulators. \u003cbr\u003e\u003cbr\u003eStructurally, Apoptosis-antagonizing transcription factor contains nuclear localization signals, basic leucine zipper-like motifs, and regions for protein-protein interaction with transcription complexes. This antibody supports analysis of AATF's role in balancing survival and death signaling pathways.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=AATF - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=AATF - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=AATF - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/AATF - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=AATF+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313727853,"sku":"FY13151","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3d1b2ed0-a1b1-4bcb-b20d-d3acacb0ed82.jpg?v=1782237109","url":"https:\/\/www.ebiohippo.com\/products\/aatf-antibody-apoptosis-antagonizing-transcription-factor-bha17136053","provider":"BioHippo","version":"1.0","type":"link"}