{"product_id":"abca4-antibody-atp-binding-cassette-sub-family-a-member-4-bha17128446","title":"ABCA4 Antibody \/ ATP-binding cassette sub-family A member 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eABCA4 Antibody \/ ATP-binding cassette sub-family A member 4 is an antibody targeting \u003cstrong\u003eABCA4\u003c\/strong\u003e, raised in \u003cstrong\u003eGoat\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ABCA4 (reported localization: Membrane, ER, Cytoplasmic vesicles).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (goat origin); Goat Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e IF, ELISA (peptide) (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eThe ABCA4 protein is a transporter molecule responsible for moving retinal molecules across cell membranes in the eye and may have a broader impact on neurological processes. Research has shown that this protein is not restricted to the eyes, but is also present in various regions of the brain. ABCA4 plays a role in the maintenance of lipid homeostasis in the central nervous system. Lipids are essential components of cell membranes and are crucial for neuronal function. Disruptions in lipid metabolism have been implicated in numerous neurological disorders, including Alzheimer's disease and Parkinson's disease. ABCA4 has been found to interact with other proteins involved in synaptic transmission and neuronal signaling. This suggests that the protein may play a role in modulating communication between neurons, which is essential for cognitive function.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eImmunofluorescence: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eELISA: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry P16284 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P16284 - Gene search: ABCA4 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ABCA4 - Ensembl search: ABCA4 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ABCA4 - PubMed search: ABCA4 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ABCA4+antibody - Reactome search: ABCA4 — Reactome — https:\/\/reactome.org\/content\/query?q=ABCA4 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5 mg\/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide \/ 100 ug","offer_id":53046420308333,"sku":"R36498-100UG","price":475.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_654ea6ac-2004-4232-a3ba-6db2cb2ffa58.jpg?v=1772000538","url":"https:\/\/www.ebiohippo.com\/products\/abca4-antibody-atp-binding-cassette-sub-family-a-member-4-bha17128446","provider":"BioHippo","version":"1.0","type":"link"}