{"product_id":"acaca-antibody-acetyl-coa-carboxylase-1-bha17136194","title":"ACACA Antibody \/ Acetyl CoA Carboxylase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eACACA Antibody \/ Acetyl CoA Carboxylase 1 is a anti-ACACA Rabbit antibody Recombinant Rabbit Monoclonal clone 32A06 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ACACA\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32A06, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eACACA antibody detects Acetyl CoA carboxylase 1, encoded by the ACACA gene. Acetyl CoA carboxylase 1 is a biotin dependent enzyme that catalyzes the conversion of acetyl CoA to malonyl CoA, the rate limiting step of fatty acid biosynthesis. ACACA antibody provides researchers with a specific reagent to study lipid metabolism, metabolic disease, and cancer biology.\u003cbr\u003e\u003cbr\u003eAcetyl CoA carboxylase 1 functions by adding a carboxyl group to acetyl CoA, producing malonyl CoA, which serves as the building block for fatty acid elongation. Research using ACACA antibody has demonstrated that this enzyme is highly expressed in lipogenic tissues such as liver and adipose tissue. By controlling malonyl CoA levels, Acetyl CoA carboxylase 1 regulates lipid synthesis and contributes to energy balance.\u003cbr\u003e\u003cbr\u003eStudies with ACACA antibody have revealed that Acetyl CoA carboxylase 1 is subject to complex regulation. It is activated by citrate, which reflects nutrient abundance, and inhibited by phosphorylation through AMP activated protein kinase under energy stress conditions. This ensures that fatty acid synthesis occurs only when energy is sufficient. Hormones such as insulin also stimulate Acetyl CoA carboxylase 1 activity, further linking the enzyme to metabolic signaling pathways.\u003cbr\u003e\u003cbr\u003eDysregulation of Acetyl CoA carboxylase 1 has been associated with obesity, diabetes, and cancer. Research using ACACA antibody has shown that elevated activity promotes lipid accumulation and insulin resistance, while inhibition of the enzyme improves metabolic outcomes in animal models. In cancer, increased Acetyl CoA carboxylase 1 expression supports tumor growth by fueling lipid synthesis required for membrane production and signaling. These findings highlight its therapeutic potential in both metabolic and oncologic diseases.\u003cbr\u003e\u003cbr\u003eACACA antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length protein and phosphorylated forms, immunohistochemistry demonstrates tissue distribution in metabolic organs, and immunofluorescence shows cytoplasmic localization associated with lipid droplets. These applications make ACACA antibody indispensable for metabolic research.\u003cbr\u003e\u003cbr\u003eBy supplying validated ACACA antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ACACA - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ACACA - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ACACA - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ACACA - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ACACA+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047321919853,"sku":"FY13292","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/acaca-antibody-acetyl-coa-carboxylase-1-bha17136194","provider":"BioHippo","version":"1.0","type":"link"}