{"product_id":"acadvl-antibody-vlcad-bha17135227","title":"ACADVL Antibody \/ VLCAD","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eACADVL Antibody \/ VLCAD is a anti-ACADVL Rabbit antibody Recombinant Rabbit Monoclonal clone 32A31 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ACADVL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32A31, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eACADVL antibody is designed to detect very long-chain specific acyl-CoA dehydrogenase (VLCAD), a mitochondrial enzyme encoded by the ACADVL gene. VLCAD is a key enzyme in the mitochondrial fatty acid beta-oxidation pathway, responsible for catalyzing the initial dehydrogenation of very long-chain acyl-CoA substrates. This activity is essential for energy production, especially during fasting or prolonged exercise when fatty acids serve as a major energy source. VLCAD is located on the inner mitochondrial membrane and plays a central role in maintaining metabolic balance and ATP generation.\u003cbr\u003e\u003cbr\u003eACADVL antibody is an important tool in metabolic and mitochondrial research. Deficiency of VLCAD due to mutations in the ACADVL gene leads to very long-chain acyl-CoA dehydrogenase deficiency, an inherited metabolic disorder characterized by hypoglycemia, cardiomyopathy, and muscle weakness. By detecting VLCAD expression and localization, researchers can investigate the molecular basis of fatty acid oxidation disorders and explore therapeutic approaches.\u003cbr\u003e\u003cbr\u003eApplications of ACADVL antibody include western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, the antibody specifically detects VLCAD protein, enabling comparison of expression across tissues and experimental conditions. Immunohistochemistry provides mitochondrial localization patterns in tissue sections, while immunofluorescence highlights subcellular distribution in cultured cells. These applications make the antibody useful for both clinical research and basic studies of metabolism.\u003cbr\u003e\u003cbr\u003eIn addition to its clinical relevance, VLCAD has been linked to metabolic regulation in cancer and cardiovascular disease. Altered fatty acid oxidation is a hallmark of many cancers, and modulation of VLCAD activity influences tumor growth and metabolic reprogramming. In cardiology, VLCAD function is crucial for sustaining energy production in heart tissue, particularly under stress. Using ACADVL antibody, researchers can study how VLCAD expression correlates with disease progression and therapeutic outcomes.\u003cbr\u003e\u003cbr\u003eBeyond disease-focused research, ACADVL antibody supports investigations into exercise physiology, fasting metabolism, and mitochondrial adaptation. By monitoring VLCAD activity, scientists gain insights into how energy metabolism adjusts under varying nutritional and physiological states. This makes the antibody valuable for a wide range of experimental designs.\u003cbr\u003e\u003cbr\u003eACADVL antibody offered by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ACADVL - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ACADVL - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ACADVL - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ACADVL - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ACADVL+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047285350765,"sku":"FY12324","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_58dc8be5-1d7b-463b-aa75-2b5c68f072f2.jpg?v=1772019281","url":"https:\/\/www.ebiohippo.com\/products\/acadvl-antibody-vlcad-bha17135227","provider":"BioHippo","version":"1.0","type":"link"}