{"product_id":"ace2-antibody-angiotensin-converting-enzyme-2-bha17135317","title":"ACE2 Antibody \/ Angiotensin-converting enzyme 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eACE2 Antibody \/ Angiotensin-converting enzyme 2 is a anti-ACE2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ACE2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe ACE2 antibody targets Angiotensin-converting enzyme 2, a type I membrane glycoprotein encoded by the ACE2 gene. Angiotensin-converting enzyme 2 functions as a carboxypeptidase that cleaves angiotensin II to angiotensin (1-7), a peptide with vasodilatory and anti-inflammatory effects. By opposing the classical renin-angiotensin system, Angiotensin-converting enzyme 2 maintains cardiovascular, renal, and pulmonary homeostasis. The ACE2 antibody provides a critical reagent for studying blood-pressure regulation, viral entry mechanisms, and tissue-specific expression of this pivotal enzyme.\u003cbr\u003e\u003cbr\u003eAngiotensin-converting enzyme 2 is expressed in the vascular endothelium, lungs, heart, kidneys, and intestinal epithelium. Its catalytic domain hydrolyzes angiotensin II to produce angiotensin (1-7), which signals through the Mas receptor to counteract vasoconstriction and fibrosis. The ACE2 antibody enables precise detection of this enzyme in tissues, helping define its role in vascular tone and inflammatory control. Loss or downregulation of ACE2 disrupts this protective axis, predisposing tissues to hypertension, oxidative stress, and organ injury.\u003cbr\u003e\u003cbr\u003eIn addition to its enzymatic role, Angiotensin-converting enzyme 2 serves as a functional receptor for several coronaviruses, including SARS-CoV and SARS-CoV-2. Viral spike proteins bind to the extracellular domain of ACE2 to mediate cell entry. The ACE2 antibody supports virology and pathogenesis studies by enabling analysis of receptor abundance and distribution across tissues. Mapping ACE2 expression helps clarify host susceptibility and disease severity patterns in respiratory and cardiovascular systems.\u003cbr\u003e\u003cbr\u003eBeyond infection biology, ACE2 participates in glucose metabolism, heart remodeling, and kidney filtration. Experimental models show that enhancing ACE2 activity mitigates cardiac hypertrophy and diabetic nephropathy. The ACE2 antibody supports quantification of these protective effects and is frequently used to monitor therapeutic modulation of the renin-angiotensin system. Dysregulated ACE2 expression has also been linked to inflammatory lung injury and endothelial dysfunction.\u003cbr\u003e\u003cbr\u003eThe ACE2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence, producing clear membrane and cytoplasmic staining consistent with its localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ACE2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ACE2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ACE2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ACE2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ACE2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285973357,"sku":"FY12414","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0c187662-4ae5-4e91-992a-bfd0d1df5248.jpg?v=1782236995","url":"https:\/\/www.ebiohippo.com\/products\/ace2-antibody-angiotensin-converting-enzyme-2-bha17135317","provider":"BioHippo","version":"1.0","type":"link"}