{"product_id":"acetyl-coenzyme-a-free-acid-bhb21200007","title":"Acetyl Coenzyme A, Free Acid","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eAcetyl Coenzyme A, Free Acid is a biochemical supplied by Coenza for use in enzymology and metabolic research. Available as Lyophilized powder, purity ≥ 95%, suitable for in vitro assays and pathway studies.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAlso known as:\u003c\/em\u003e Acetyl-Coenzyme A, Acetyl-CoA.\u003c\/p\u003e\n\u003ch2\u003eKey Elements and Design Rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula \/ MW \/ Purity:\u003c\/strong\u003e C23H38N7O17P3S; 809.57 g\/mol; ≥ 95%. The Free Acid form provides enhanced aqueous stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm \/ Solubility:\u003c\/strong\u003e Lyophilized powder; Soluble in water.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Acetyl-Coenzyme A, Acetyl-CoA.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Synthetic synthesis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eBiological Background\u003c\/h2\u003e\n\u003cp\u003eAcetyl Coenzyme A (Acetyl-CoA) is a vital molecule in cellular metabolism, serving as a central intermediate in various biochemical processes. It is synthesized by the acetylation of Coenzyme A (CoA) through enzymatic reactions involving pyruvate dehydrogenase, ?-oxidation of fatty acids, and amino acid catabolism. The unique structure of Acetyl-CoA, with its reactive acetyl group, allows it to participate in numerous biochemical reactions, including the tricarboxylic acid (TCA) cycle, fatty acid synthesis, and cholesterol metabolism, making it an essential cofactor in cellular energy production and biosynthetic pathways (Pietrocola et al., 2015; Shi \u0026amp; Tu, 2015).\u003c\/p\u003e\n\u003ch2\u003eResearch Relevance and Current Trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcyl-CoA metabolism increasingly linked to histone acylation marks and epigenetic regulation in cancer and metabolic disease research.\u003c\/li\u003e\n\u003cli\u003eGrowing interest in short-chain fatty acid CoA thioesters as mediators of gut microbiome–host metabolic crosstalk.\u003c\/li\u003e\n\u003cli\u003eCoA-dependent enzymes investigated as drug targets in infectious disease and neurometabolic disorder research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon Research Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEnzyme kinetics assays — direct substrate for acyltransferases, thiolases, and dehydrogenases.\u003c\/li\u003e\n\u003cli\u003eMetabolic flux analysis — isotope-labeled variants available for stable-isotope tracing.\u003c\/li\u003e\n\u003cli\u003eIn vitro pathway reconstitution for fatty acid β-oxidation, TCA cycle, or polyketide biosynthesis.\u003c\/li\u003e\n\u003cli\u003eBiochemical characterization of CoA-binding proteins by activity assays or binding measurements.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eNotes for Experimental Interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCoA thioesters hydrolyze at neutral–alkaline pH; prepare working solutions fresh and keep on ice.\u003c\/li\u003e\n\u003cli\u003eDifferent salt forms share the same core structure — normalize concentrations using the free-acid MW when comparing across forms.\u003c\/li\u003e\n\u003cli\u003eThiol oxidation may occur upon air exposure; use under inert atmosphere or with reducing agents where appropriate.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Coenza","offers":[{"title":"10 mg","offer_id":53249725268333,"sku":"A-20-10MG","price":136.4,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53249732936045,"sku":"A-20-25MG","price":284.1,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53249732968813,"sku":"A-20-50MG","price":488.7,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53249733001581,"sku":"A-20-100MG","price":863.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/53dbfa_4f88405582024e3db0f4a4e2a4f804d1_mv2.png?v=1776855582","url":"https:\/\/www.ebiohippo.com\/products\/acetyl-coenzyme-a-free-acid-bhb21200007","provider":"BioHippo","version":"1.0","type":"link"}