{"product_id":"acp2-antibody-lysosomal-acid-phosphatase-2-bha17135563","title":"ACP2 Antibody \/ Lysosomal acid phosphatase 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eACP2 Antibody \/ Lysosomal acid phosphatase 2 is a anti-ACP2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ACP2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eACP2 antibody detects Lysosomal acid phosphatase 2, an enzyme responsible for the hydrolysis of phosphate esters within the acidic environment of lysosomes. ACP2 plays an essential role in the degradation of macromolecules, phosphate turnover, and lysosomal homeostasis. It functions as part of a larger lysosomal complex that regulates both nutrient recycling and intracellular signaling. The ACP2 antibody is widely used in cell biology, metabolism, and pathology research to study lysosomal function, enzyme regulation, and metabolic disorders.\u003cbr\u003e\u003cbr\u003eACP2 is encoded by the ACP2 gene located on human chromosome 11p11.2. The protein is approximately 452 amino acids in length and is synthesized as a precursor that undergoes proteolytic cleavage into two subunits�a 36 kilodalton alpha subunit and a 14 kilodalton beta subunit�that together form the active enzyme. ACP2 localizes predominantly to the lysosomal lumen but can also be detected in late endosomes and phagosomes, reflecting its involvement in diverse degradative pathways.\u003cbr\u003e\u003cbr\u003eThe ACP2 antibody detects the 50 kilodalton precursor and its processed subunits by western blot and shows punctate lysosomal staining by immunofluorescence microscopy. ACP2 participates in the hydrolysis of phosphate-containing substrates derived from nucleotides, phospholipids, and other macromolecules, releasing inorganic phosphate for metabolic reuse. It complements the function of acid phosphatase ACP3, ensuring redundancy in phosphate metabolism and cellular cleanup.\u003cbr\u003e\u003cbr\u003eMutations or deficiencies in ACP2 lead to acid phosphatase deficiency, a rare lysosomal storage disorder characterized by abnormal accumulation of phosphomonoesters and progressive neurodegeneration. Reduced ACP2 activity has also been implicated in osteopetrosis-like bone disorders and altered immune responses, as lysosomal enzymes regulate antigen presentation and macrophage function. Conversely, upregulation of ACP2 is observed during macrophage activation and tissue remodeling, highlighting its adaptive role in immune and metabolic balance.\u003cbr\u003e\u003cbr\u003eAs a lysosomal hydrolase linking phosphate metabolism to intracellular clearance, ACP2 is a valuable marker for lysosome integrity and metabolic health.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ACP2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ACP2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ACP2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ACP2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ACP2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047296721261,"sku":"FY12660","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d6c7bc28-5c41-4e1b-95ae-96714b38fdc0.jpg?v=1782237029","url":"https:\/\/www.ebiohippo.com\/products\/acp2-antibody-lysosomal-acid-phosphatase-2-bha17135563","provider":"BioHippo","version":"1.0","type":"link"}