{"product_id":"actr1b-antibody-actin-related-protein-1b-bha17135694","title":"ACTR1B Antibody \/ Actin related protein 1B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eACTR1B Antibody \/ Actin related protein 1B is a anti-ACTR1B Rabbit antibody Recombinant Rabbit Monoclonal clone 30A59 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow cytometry (FACS) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ACTR1B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30A59, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eACTR1B antibody detects actin related protein 1B, encoded by the ACTR1B gene. Other identifiers include ARP1 beta and actin like protein 1B. ACTR1B is a component of the dynactin complex, which links cytoplasmic dynein motors to cargo for microtubule based transport. As a structural actin related protein, ACTR1B forms a short filament within dynactin that resembles conventional actin but has specialized roles in motor attachment. This arrangement enables the dynactin complex to couple vesicles, organelles, and protein complexes to dynein, allowing retrograde transport along microtubules.\u003cbr\u003e\u003cbr\u003eACTR1B antibody is widely applied in neuroscience, cell biology, and developmental biology. By detecting ACTR1B, researchers can evaluate how dynein dynactin interactions support intracellular transport. This process is essential for neuronal function, where long distance axonal transport delivers synaptic vesicles and organelles. Mutations or disruption of dynactin subunits, including ACTR1B, impair axonal transport and cause neurodegenerative disease. ACTR1B expression is detected in brain, muscle, and immune cells, reflecting its broad roles in intracellular logistics.\u003cbr\u003e\u003cbr\u003eApplications of ACTR1B antibody include western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects ACTR1B protein in neuronal lysates, immunohistochemistry maps expression in brain sections, and immunofluorescence reveals localization along microtubules and vesicular cargo. These approaches allow direct visualization of dynactin function in cellular transport.\u003cbr\u003e\u003cbr\u003eDynactin acts as a cofactor for dynein in multiple processes, including mitotic spindle orientation, endosome trafficking, and immune synapse formation. By applying ACTR1B antibody, scientists can study how transport machinery coordinates cell division, signaling, and migration. In developmental biology, ACTR1B is required for correct neuronal wiring and tissue morphogenesis, as transport defects disrupt growth cone guidance and organelle distribution.\u003cbr\u003e\u003cbr\u003eAberrant dynactin activity contributes to neurodegenerative diseases such as amyotrophic lateral sclerosis and hereditary spastic paraplegia. While most mutations involve the p150Glued subunit, ACTR1B remains essential for filament integrity. Detection with ACTR1B antibody provides a foundation for exploring dynactin biology in disease contexts. In cancer, altered microtubule transport and polarity also involve dynactin regulation, linking ACTR1B studies to oncology.\u003cbr\u003e\u003cbr\u003eACTR1B antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ACTR1B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ACTR1B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ACTR1B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ACTR1B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ACTR1B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047300063597,"sku":"FY12792","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2f6107bc-beb9-4576-85ea-e8c73191b2b4.jpg?v=1772019344","url":"https:\/\/www.ebiohippo.com\/products\/actr1b-antibody-actin-related-protein-1b-bha17135694","provider":"BioHippo","version":"1.0","type":"link"}