{"product_id":"acvr2a-antibody-activin-receptor-type-2a-bha17136259","title":"ACVR2A Antibody \/ Activin receptor type-2A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eACVR2A Antibody \/ Activin receptor type-2A is a anti-ACVR2A Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ACVR2A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eACVR2A antibody detects Activin receptor type-2A, a transmembrane serine\/threonine kinase receptor encoded by the ACVR2A gene on chromosome 2q22.2. ACVR2A is a member of the transforming growth factor beta receptor family and functions as a type II receptor for activins, inhibins, and related growth factors. It is broadly expressed in reproductive organs, liver, skeletal muscle, and nervous tissue, mediating diverse biological processes including cell growth, differentiation, and embryonic patterning. ACVR2A serves as a central component in activin-mediated signaling that controls reproduction, metabolism, and tissue repair.\u003cbr\u003e\u003cbr\u003eACVR2A binds activin A, activin B, and growth differentiation factors such as GDF8 (myostatin) and GDF11, initiating phosphorylation of type I receptor partners (ALK4\/ALK7). This triggers SMAD2 and SMAD3 activation and downstream transcriptional responses that regulate gene expression in target tissues. Co-localization studies show ACVR2A clustering with ALK4 at the plasma membrane and endosomal compartments, where ligand-induced receptor internalization fine-tunes signaling output.\u003cbr\u003e\u003cbr\u003eStructurally, ACVR2A features an extracellular ligand-binding domain, a single transmembrane region, and an intracellular kinase domain responsible for catalytic activity. It belongs to the transforming growth factor beta receptor family of serine\/threonine kinases, sharing sequence homology with ACVR2B. The receptor interacts with ligands and type I receptors to form heterotetrameric complexes required for signal propagation. Known ligands include activins, inhibins, GDF8, and GDF11, which influence muscle growth, reproductive physiology, and developmental patterning.\u003cbr\u003e\u003cbr\u003eFunctionally, ACVR2A mediates activin signaling involved in follicle-stimulating hormone regulation, gonadal development, and muscle differentiation. It also participates in metabolic control, modulating insulin sensitivity and energy expenditure. During embryogenesis, ACVR2A expression is essential for mesoderm formation, neural tube development, and left-right axis determination. In adult tissues, ACVR2A supports tissue regeneration and wound repair by activating SMAD-dependent transcriptional networks.\u003cbr\u003e\u003cbr\u003eDysregulation of ACVR2A signaling contributes to reproductive disorders, cancer, and muscle-wasting diseases. Loss-of-function mutations can impair fertility, while overactivation has been linked to tumor progression through transforming growth factor beta pathway cross-talk. In hepatocellular carcinoma, reduced ACVR2A expression correlates with increased proliferation and metastasis. Pathway associations include transforming growth factor beta, SMAD, and MAPK signaling networks, which coordinate growth and differentiation across cell types. Isoform-specific studies reveal that ACVR2A and its paralog ACVR2B exhibit distinct ligand affinities and tissue distributions, allowing fine-tuned activin signaling.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using ACVR2A antibody shows membrane and cytoplasmic localization in reproductive, hepatic, and neural tissues. The ACVR2A antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ACVR2A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ACVR2A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ACVR2A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ACVR2A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ACVR2A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047323296109,"sku":"FY13357","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d2621fec-8de7-491d-88c0-b5c044acb3fd.jpg?v=1782237106","url":"https:\/\/www.ebiohippo.com\/products\/acvr2a-antibody-activin-receptor-type-2a-bha17136259","provider":"BioHippo","version":"1.0","type":"link"}