{"product_id":"adamts1-antibody-a-disintegrin-and-metalloproteinase-with-thrombospondin-motifs-1-bha17135837","title":"ADAMTS1 Antibody \/ A disintegrin and metalloproteinase with thrombospondin motifs 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eADAMTS1 Antibody \/ A disintegrin and metalloproteinase with thrombospondin motifs 1 is a anti-ADAMTS1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ADAMTS1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eADAMTS1 antibody detects A disintegrin and metalloproteinase with thrombospondin motifs 1, a secreted protease involved in extracellular matrix remodeling, angiogenesis, and inflammation. The UniProt recommended name is A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), with alternate names METH1, ADAM-TS1, and protease METH-1. ADAMTS1 belongs to the ADAMTS family of zinc-dependent proteases characterized by metalloprotease, disintegrin-like, and thrombospondin type 1 (TSP-1) domains that coordinate matrix turnover and growth factor regulation.\u003cbr\u003e\u003cbr\u003eFunctionally, ADAMTS1 antibody recognizes a multi-domain enzyme that cleaves proteoglycans such as aggrecan and versican, controlling tissue remodeling during development, wound healing, and pathological fibrosis. ADAMTS1 also regulates angiogenesis by inhibiting endothelial cell proliferation and migration, in part through sequestration of VEGF signaling. The enzyme is expressed in many tissues including heart, kidney, and placenta, and its upregulation occurs in response to inflammatory cytokines, mechanical stress, and injury. ADAMTS1 participates in ovulation, cardiac morphogenesis, and tumor microenvironment remodeling.\u003cbr\u003e\u003cbr\u003eMutations or dysregulated expression of ADAMTS1 contribute to cardiovascular disease, cancer progression, and arthritis. Studies show reduced ADAMTS1 expression enhances tumor growth by promoting vascularization, whereas overexpression suppresses angiogenesis and metastasis. In the vascular system, ADAMTS1 modulates smooth muscle cell migration and matrix elasticity, maintaining vessel wall integrity. ADAMTS1 antibody is used to evaluate expression patterns and enzymatic activity via immunohistochemistry, zymography, and ELISA assays.\u003cbr\u003e\u003cbr\u003eThe ADAMTS1 gene, located on chromosome 21q21.3, encodes a 967-amino acid secreted glycoprotein activated by furin cleavage. Post-translational modifications, including glycosylation and proteolytic processing, regulate its localization and activity in the extracellular matrix. Interaction with TIMPs (tissue inhibitors of metalloproteinases) and integrins helps fine-tune its catalytic balance. In development, ADAMTS1 is crucial for follicular rupture during ovulation, kidney branching morphogenesis, and skeletal formation.\u003cbr\u003e\u003cbr\u003eBy targeting a central ECM protease, the ADAMTS1 antibody enables in-depth study of extracellular remodeling and angiogenic signaling in physiology and pathology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ADAMTS1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ADAMTS1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ADAMTS1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ADAMTS1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ADAMTS1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306223981,"sku":"FY12935","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1b17abc9-d275-4b5d-8749-ca0a8b3c5e53.jpg?v=1782237062","url":"https:\/\/www.ebiohippo.com\/products\/adamts1-antibody-a-disintegrin-and-metalloproteinase-with-thrombospondin-motifs-1-bha17135837","provider":"BioHippo","version":"1.0","type":"link"}