{"product_id":"afuresertib-hydrochloride-bhb20443218","title":"Afuresertib hydrochloride","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eAfuresertib hydrochloride\u003c\/strong\u003e (CAS 1047645-82-8) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Afuresertib hydrochloride\u003c\/p\u003e\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e1047645-82-8\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC18H18Cl3FN4OS\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e463.80 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eCl.Cn1ncc(Cl)c1-c1cc(C(=O)NC(CN)Cc2cccc(F)c2)sc1Cl\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eAfuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08\/2\/2.6 nM for Akt1\/Akt2\/Akt3 respectively)\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e ROCK, Akt, PKC\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e Stem Cells, Cell Cycle\/Checkpoint, Chromatin\/Epigenetic, Cytoskeletal Signaling, PI3K\/Akt\/mTOR signaling\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"2 mg","offer_id":53327274901869,"sku":"T7885-2MG","price":44.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53327525052781,"sku":"T7885-5MG","price":68.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327525085549,"sku":"T7885-1MLX10MM","price":78.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327525118317,"sku":"T7885-10MG","price":96.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327525151085,"sku":"T7885-25MG","price":166.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327525183853,"sku":"T7885-50MG","price":266.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327525216621,"sku":"T7885-100MG","price":460.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":53327525249389,"sku":"T7885-200MG","price":598.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEWayHiuEa335AAAAAB9dScY027.png?v=1778722284","url":"https:\/\/www.ebiohippo.com\/products\/afuresertib-hydrochloride-bhb20443218","provider":"BioHippo","version":"1.0","type":"link"}