{"product_id":"alpha-a-crystallin-antibody-bha11900620","title":"Alpha-A Crystallin Antibody","description":"\u003cp\u003eAlpha A Crystallin (CRYAA) is a member of the small heat shock protein (sHSP) family and a major structural component of the vertebrate eye lens. Traditionally recognized for its role in maintaining lens transparency and refractive properties, CRYAA is now gaining attention in neuroscience for its molecular chaperone activity and neuroprotective potential.\u003c\/p\u003e\n\n\u003cp\u003eCRYAA prevents protein aggregation by binding to partially unfolded or denatured proteins, a function critical in the context of neurodegenerative diseases characterized by protein misfolding, such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Under cellular stress, CRYAA undergoes phosphorylation, enhancing its chaperone function and contributing to protein homeostasis.\u003c\/p\u003e\n\n\u003cp\u003eBeyond the lens, CRYAA is expressed in various tissues and interacts with a wide range of cellular components, including membrane proteins, nuclear proteins, Golgi matrix proteins, and even DNA. These interactions suggest broader roles in intracellular architecture, signal transduction, and genomic stability.\u003c\/p\u003e\n\n\u003cp\u003eImportantly, both Alpha A and Alpha B Crystallins exhibit anti-apoptotic properties by inhibiting caspase activation, positioning them as potential modulators of neuronal survival. CRYAA’s autokinase activity and involvement in cytoskeletal dynamics further support its relevance in maintaining neuronal integrity under stress.\u003c\/p\u003e\n\n\u003cp\u003eAs interest grows in targeting molecular chaperones for neurodegenerative therapy, CRYAA stands out as a promising candidate for biomarker development, therapeutic delivery, and cellular resilience enhancement in the aging and diseased brain.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040786702701,"sku":"SMC-142B","price":301.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040804397421,"sku":"SMC-142B-A390","price":405.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040804430189,"sku":"SMC-142B-A488","price":402.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040804462957,"sku":"SMC-142B-A594","price":402.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040804495725,"sku":"SMC-142B-APC","price":401.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040804528493,"sku":"SMC-142B-BI","price":392.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040804561261,"sku":"SMC-142B-FITC","price":384.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040804594029,"sku":"SMC-142B-HRP","price":377.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040804626797,"sku":"SMC-142B-PCP","price":401.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040804659565,"sku":"SMC-142B-RPE","price":394.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040804692333,"sku":"SMC-142S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-142-Alpha-A-Crystallin-Antibody-1H3B8-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png?v=1771832134","url":"https:\/\/www.ebiohippo.com\/products\/alpha-a-crystallin-antibody-bha11900620","provider":"BioHippo","version":"1.0","type":"link"}