{"product_id":"alpha-synuclein-antibody-pser129-bha11933271","title":"RECOMBINANT Alpha Synuclein Antibody (pSer129)","description":"\u003cp\u003eAlpha-synuclein (SNCA) is a neuronal protein predominantly expressed in the brain, where it is enriched at presynaptic terminals and plays a key role in synaptic function (1). It is also highly expressed in mitochondria-rich regions such as the olfactory bulb, hippocampus, striatum, and thalamus, suggesting a role in mitochondrial dynamics and neuronal energy metabolism (2). Functionally, alpha-synuclein interacts with tubulin (3), indicating a potential role as a microtubule-associated protein involved in cytoskeletal organization and intracellular transport. It is essential for cognitive development, with SNCA inactivation linked to impaired spatial learning and working memory (4).\u003c\/p\u003e\n\n\u003cp\u003ePathologically, SNCA aggregates are a major non-Aβ component of amyloid plaques in Alzheimer’s disease and a defining feature of Lewy body inclusions in Parkinson’s disease (PD). PD is characterized by the progressive accumulation of alpha-synuclein and ubiquitin-positive inclusions in vulnerable neurons, contributing to neurodegeneration (5, 6).\u003c\/p\u003e\n\n\u003cp\u003eCritically, phosphorylation of alpha-synuclein at serine 129 (pSer129) is a key post-translational modification associated with disease pathology. Approximately 90% of alpha-synuclein found in Lewy bodies is phosphorylated at Ser129, compared to only a small fraction in the healthy brain (7, 8). This modification is widely used as a biomarker for pathological alpha-synuclein and is a focal point in therapeutic and diagnostic research targeting synucleinopathies.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040795910509,"sku":"SMC-600D","price":487.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040897163629,"sku":"SMC-600D-A390","price":541.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040897196397,"sku":"SMC-600D-A488","price":540.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040897229165,"sku":"SMC-600D-A594","price":540.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040897261933,"sku":"SMC-600D-APC","price":539.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040897294701,"sku":"SMC-600D-BI","price":536.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040897327469,"sku":"SMC-600D-FITC","price":530.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040897360237,"sku":"SMC-600D-HRP","price":526.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040897393005,"sku":"SMC-600D-PCP","price":539.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040897425773,"sku":"SMC-600D-RPE","price":537.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040897458541,"sku":"SMC-600S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-600_Alpha-Synuclein-pSer129_Antibody_J18_IHC_Mouse_Brain_1.png?v=1771832170","url":"https:\/\/www.ebiohippo.com\/products\/alpha-synuclein-antibody-pser129-bha11933271","provider":"BioHippo","version":"1.0","type":"link"}