{"product_id":"amyloid-beta-1-42-oligomer-antibody-bha11933479","title":"RECOMBINANT Amyloid Beta 1-42 Oligomer Antibody","description":"\u003cp\u003eAmyloid beta (Aβ) peptide, particularly the 1-42 isoform (Aβ1-42), plays a central role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated through proteolytic cleavage of the amyloid precursor protein (APP) and can self-assemble into a range of aggregated species, including oligomers, protofibrils, fibrils, and ultimately extracellular plaques. Among these, Aβ1-42 oligomers are increasingly recognized as the most neurotoxic species, contributing to synaptic dysfunction, neuroinflammation, and cognitive decline.\u003c\/p\u003e\n\n\u003cp\u003eOur amyloid beta oligomer antibody has been validated for high specificity toward Aβ1-42 oligomers, distinguishing them from other aggregated forms. This specificity is critical for accurately detecting early-stage, soluble aggregates that precede plaque formation and are believed to drive early neurodegenerative changes in AD (1).\u003c\/p\u003e\n\n\u003cp\u003eThe immunogen used to generate these oligomers was Amyloid Beta Peptide 1-42, pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP), following established protocols to ensure reproducible oligomer formation (2, 3). This preparation method enhances the structural fidelity of oligomeric species, enabling more precise investigation of their pathological roles.\u003c\/p\u003e\n\n\u003cp\u003eGiven that most therapeutic strategies over the past two decades have targeted Aβ accumulation, tools that selectively recognize Aβ1-42 oligomers are essential for advancing both basic research and translational efforts in Alzheimer’s disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040796860781,"sku":"SMC-619D","price":536.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040902734189,"sku":"SMC-619D-A390","price":585.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040902766957,"sku":"SMC-619D-A488","price":584.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040902799725,"sku":"SMC-619D-A594","price":584.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040902832493,"sku":"SMC-619D-APC","price":583.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040902865261,"sku":"SMC-619D-BI","price":580.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040902898029,"sku":"SMC-619D-FITC","price":576.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040902930797,"sku":"SMC-619D-HRP","price":572.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040902963565,"sku":"SMC-619D-PCP","price":583.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040902996333,"sku":"SMC-619D-RPE","price":581.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040903029101,"sku":"SMC-619S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-619_Amyloid-Beta-1-42-Oligomer_Antibody_1C1_WB_Human_Purified-protein_1.png?v=1771832173","url":"https:\/\/www.ebiohippo.com\/products\/amyloid-beta-1-42-oligomer-antibody-bha11933479","provider":"BioHippo","version":"1.0","type":"link"}