{"product_id":"ankyrin-g-antibody-bha11903583","title":"Ankyrin G Antibody","description":"\u003cp\u003eAnkyrin-G (ANK3) is a critical scaffolding protein that anchors integral membrane proteins to the spectrin-actin cytoskeleton, ensuring the structural and functional integrity of excitable cells, particularly neurons. It binds to the β-spectrin subunit and a wide array of membrane proteins, including voltage-gated sodium channels, potassium channels, and cell adhesion molecules, orchestrating their precise localization at the axon initial segment (AIS) and nodes of Ranvier.\u003c\/p\u003e\n\n\u003cp\u003eIn the central nervous system, Ankyrin-G plays a pivotal role in maintaining neuronal polarity, regulating action potential initiation, and preserving synaptic stability. Disruption of Ankyrin-G function leads to mislocalization of ion channels and cytoskeletal disorganization, contributing to impaired neuronal signaling.\u003c\/p\u003e\n\n\u003cp\u003eEmerging evidence links ANK3 mutations and dysregulation to a spectrum of neuropsychiatric and neurodegenerative disorders, including bipolar disorder, schizophrenia, epilepsy, and Alzheimer’s disease. In Alzheimer’s models, Ankyrin-G dysfunction has been associated with AIS disassembly and increased neuronal vulnerability, suggesting a mechanistic link between cytoskeletal breakdown and neurodegeneration.\u003c\/p\u003e\n\n\u003cp\u003eGiven its central role in neuronal architecture and excitability, Ankyrin-G is increasingly recognized as a potential biomarker and therapeutic target in neurodegenerative disease research. Understanding its molecular interactions and regulatory mechanisms is essential for developing strategies to preserve neuronal function and prevent disease progression.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040789455213,"sku":"SMC-404D","price":337.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040826712429,"sku":"SMC-404D-A390","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040826745197,"sku":"SMC-404D-A488","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040826777965,"sku":"SMC-404D-A594","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040826810733,"sku":"SMC-404D-APC","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040826843501,"sku":"SMC-404D-BI","price":386.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040826876269,"sku":"SMC-404D-FITC","price":381.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040826909037,"sku":"SMC-404D-HRP","price":377.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040826941805,"sku":"SMC-404D-PCP","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040826974573,"sku":"SMC-404D-RPE","price":388.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040827007341,"sku":"SMC-404S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-404_Ankyrin-G_Antibody_N106-20_ICC-IF_Human_Neuroblastoma-cells-SH-SY5Y-Composite-1.png?v=1771832143","url":"https:\/\/www.ebiohippo.com\/products\/ankyrin-g-antibody-bha11903583","provider":"BioHippo","version":"1.0","type":"link"}