{"product_id":"annexin-a7-antibody-anxa7-bha17135414","title":"Annexin A7 Antibody \/ ANXA7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eAnnexin A7 Antibody \/ ANXA7 is a anti-A7 Rabbit antibody Recombinant Rabbit Monoclonal clone 30A75 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e A7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30A75, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eAnnexin A7 antibody detects annexin A7, a calcium and phospholipid binding protein encoded by the ANXA7 gene. Annexin A7 belongs to the annexin protein family, which share conserved annexin repeat domains that mediate calcium dependent membrane interactions. This protein participates in exocytosis, membrane fusion, and calcium signaling, making it a key regulator of vesicular transport and cellular communication across multiple tissues.\u003cbr\u003e\u003cbr\u003eAnnexin A7 antibody is widely applied in neuroscience, cardiovascular biology, and oncology. In the nervous system, annexin A7 contributes to synaptic vesicle release and neurotransmitter secretion. In cardiac muscle, it supports calcium handling and myocardial contractility. Dysregulation of annexin A7 has been associated with several cancers, where it influences tumor growth, cell motility, and drug resistance. By detecting annexin A7, researchers can study its role in both normal physiology and disease mechanisms.\u003cbr\u003e\u003cbr\u003eIn western blot assays, annexin A7 antibody identifies protein bands of the expected molecular weight in tissue lysates. Immunohistochemistry maps annexin A7 expression in brain, heart, and epithelial tissues, while immunofluorescence highlights cytoplasmic and membrane localization. These applications enable detailed analysis of annexin A7 in cellular signaling and trafficking.\u003cbr\u003e\u003cbr\u003eAnnexin A7 is involved in calcium dependent regulation of phospholipase activity and contributes to processes including apoptosis, proliferation, and membrane repair. Altered expression has been linked to cancer biology, cardiovascular disorders, and neurological diseases. In oncology, annexin A7 has been studied as both a tumor suppressor and promoter, depending on cellular context. By applying annexin A7 antibody, scientists can investigate how annexin mediated pathways affect tumor progression and therapy response.\u003cbr\u003e\u003cbr\u003eBeyond cancer and cardiovascular research, annexin A7 also plays roles in endocrine function, fertility, and immune signaling. Its presence in secretory cells suggests contributions to hormone release and immune mediator secretion. These diverse functions emphasize the importance of annexin A7 as a research target across multiple biological systems.\u003cbr\u003e\u003cbr\u003eAnnexin A7 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=A7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=A7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=A7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/A7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=A7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047291216237,"sku":"FY12511","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ba896114-85b2-44f1-af72-14e7eed7a6e5.jpg?v=1772019302","url":"https:\/\/www.ebiohippo.com\/products\/annexin-a7-antibody-anxa7-bha17135414","provider":"BioHippo","version":"1.0","type":"link"}