{"product_id":"anti-cyclin-h-p34-rabbit-monoclonal-antibody-bha21010339","title":"Anti-Cyclin H\/p34 Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-Cyclin H\/p34 Rabbit Monoclonal Antibody catalog # M03013-3. Tested in WB application. This antibody reacts with Human, Mouse, Rat.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein\u003c\/strong\u003e: T-cell surface glycoprotein CD3 zeta chain | \u003cstrong\u003eGene\u003c\/strong\u003e: Cyclin-H | \u003cstrong\u003eTarget\u003c\/strong\u003e: CCNH | \u003cstrong\u003eFunction\u003c\/strong\u003e: Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Cell Biology,Cell Cycle,Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 28C49 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human,Mouse,Rat | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human Cyclin H\/p34 | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 35 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 37643 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Nucleus.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Activated T-lymphocytes.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072124051821,"sku":"M03013-3","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/m03013-3-wb.jpg?v=1772621954","url":"https:\/\/www.ebiohippo.com\/products\/anti-cyclin-h-p34-rabbit-monoclonal-antibody-bha21010339","provider":"BioHippo","version":"1.0","type":"link"}