{"product_id":"anti-fcgr3a-cd16a-igg-antibody-biotin-labeled-bha18200072","title":"Anti-FcGR3A (CD16A) IgG Antibody, Biotin-Labeled","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\u003cdiv class=\"bhp-desc\"\u003e\n\u003cp class=\"bhp-cat-pill\"\u003eImmunotherapy\u003c\/p\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eThis anti-FcGR3A (CD16A) antibody is a purified, biotinylated, recombinant human monoclonal antibody which recognizes the human FcGR3A\/CD16A protein. Fc Gamma Receptor IIIa (FcGRIIIA; FcγRIIIA), also known as CD16a, is a low\/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity, and clearance of immune complexes. FcGR3A\/CD16A plays a role in the activation of natural killer (NK) cells. Clinically, it serves as a marker of certain immune cells such as neutrophils. CD16 expression has been observed at the surface of T cells in patients with chronic viral infections (such as COVID-19). It is considered a potential therapeutic target to potentiate the efficacy of therapeutic antibodies used to treat solid tumors, or as direct target in hematopoietic cancers. This antibody has been tested for specific binding to purified human FcGR3A\/CD16A (BPS Bioscience #79013) in an ELISA binding assay with colorimetric detection. It does not cross-react with purified human FcGR2B\/CD16B.\u003c\/p\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eHost\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAntibody Type\u003c\/th\u003e\n\u003ctd\u003eIgG1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConjugate\u003c\/th\u003e\n\u003ctd\u003eBiotin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eReactivity\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eProtein A affinity chromatography (HEK293)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e≥90%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e~150 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003e8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eAt least 12 months at -80°C.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003eWestern Blot\u003c\/li\u003e\u003c\/ul\u003e\n\u003ch2\u003eImmunogen \/ Antigen Information\u003c\/h2\u003e\n\u003cp\u003eImmunogen information not provided. Please refer to the product datasheet for detailed antigen information.\u003c\/p\u003e\n\u003ch2\u003eCross-Reactivity \u0026amp; Specificity\u003c\/h2\u003e\n\u003cp\u003eThis antibody recognizes human FcGR3A\/CD16A. It does not recognize human FcGR3B (CD16B). It has not been tested with other species\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eBiosafety Level:\u003c\/strong\u003e Not applicable (BSL-1)\u003c\/div\u003e\n\u003cp\u003eAvoid freeze\/thaw cycles.\u003c\/p\u003e\n\u003cp\u003eFor Research Use Only (RUO). Not for diagnostic, therapeutic, or clinical use. Handle with standard laboratory precautions (gloves, safety glasses, lab coat). Avoid freeze-thaw cycles. Consult SDS prior to use.\u003c\/p\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e101112\u003c\/li\u003e\n\u003cli\u003e101093\u003c\/li\u003e\n\u003cli\u003e101098\u003c\/li\u003e\n\u003cli\u003e78332\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"BPS Bioscience","offers":[{"title":"50 ug","offer_id":53327926198637,"sku":"101225-1","price":250.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53327934685549,"sku":"101225-2","price":375.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/101225_gel.png?v=1778728312","url":"https:\/\/www.ebiohippo.com\/products\/anti-fcgr3a-cd16a-igg-antibody-biotin-labeled-bha18200072","provider":"BioHippo","version":"1.0","type":"link"}