{"product_id":"anti-human-cd147-bha14700155","title":"anti-human CD147","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003cspan class=\"bhp-cat-pill\"\u003ePrimary Antibody — Monoclonal\u003c\/span\u003e\n\n  \u003ch2\u003eProduct Overview\u003c\/h2\u003e\n  \u003cp\u003eAntibody UM-8D6 recognizes extracellular epitope 2 within the n-terminal Ig domain (1) of the human CD147 molecule, about 35-40 kd (2)\u003c\/p\u003e\n\n  \u003cp\u003eHuman CD147 (EMMPRIN, Basigin) is a transmembrane glycoprotein expressed more intensely on thymocytes than on mature peripheral blood T cells. Expression of CD147 in bronchial epithelial cells has been correlated with incidence of COPD(3).\u003c\/p\u003e\n\n  \u003ch2\u003eValidated Applications\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd\u003eFlow Cytometry (FC)\u003c\/td\u003e\n\u003ctd\u003eSee datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImmunoprecipitation (IP)\u003c\/td\u003e\n\u003ctd\u003eSee datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWestern Blot (WB)\u003c\/td\u003e\n\u003ctd\u003eSee datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n\n  \u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eClone\u003c\/th\u003e\n\u003ctd\u003eUM-8D6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConjugate\u003c\/th\u003e\n\u003ctd\u003eAPC, Biotin, FITC, PE, Unconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eStore at 2 - 5°C. Freeze\/Thawing is not recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n\n  \u003ch2\u003eImmunogen \/ Antigen\u003c\/h2\u003e\n  \u003cp\u003eHuman T cell line Molt 13\u003c\/p\u003e\n\n  \u003ch2\u003eFunctional Activity\u003c\/h2\u003e\n  \u003cp\u003eUM-8D6 inhibits homotypic aggregation, adhesion to matrix proteins and migation through matrigel (1).  This antibody can inhibit homotypic induction of MMP (Matrix metalloproteinase), as well as cyclophilin mediated chemotactic resposes  (4).  It has been shown to inhibit proliferation of stimulated T cells in vitro (7). UM-8D6 is recommended for use in Western blot at 0.1 – 1 ug\/ml (5).  It works on acetone fixed frozen section IHC (6).\u003c\/p\u003e\n\n  \u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for diagnostic or therapeutic use. \n    Handle as a potential biohazard in accordance with good laboratory practices.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eRelated Products\u003c\/h2\u003e\n  \u003cp\u003eExplore complementary antibodies, ELISA kits, and detection reagents at \n  \u003ca href=\"https:\/\/www.ebiohippo.com\" target=\"_blank\"\u003eBioHippo\u003c\/a\u003e.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Ancell Corporation","offers":[{"title":"Purified (with Antibiotic) \/ 100 ug","offer_id":53328076833133,"sku":"376-020","price":240.0,"currency_code":"USD","in_stock":true},{"title":"Biotin conjugate \/ 100 ug","offer_id":53328112124269,"sku":"376-030","price":282.0,"currency_code":"USD","in_stock":true},{"title":"FITC (Fluorescein) conjugate \/ 120 tests","offer_id":53328112157037,"sku":"376-040","price":282.0,"currency_code":"USD","in_stock":true},{"title":"PE (Phycoerythrin) conjugate \/ 120 tests","offer_id":53328112189805,"sku":"376-050","price":360.0,"currency_code":"USD","in_stock":true},{"title":"APC (Allophycocyanin) conjugate \/ 120 tests","offer_id":53328112222573,"sku":"376-060","price":420.0,"currency_code":"USD","in_stock":true},{"title":"Purified (Preservative-free) \/ 100 ug","offer_id":53328112255341,"sku":"376-820","price":240.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/anti-human-cd147-bha14700155","provider":"BioHippo","version":"1.0","type":"link"}