{"product_id":"anti-human-cd45-ptprc-nanobody-2h7-bha21405339","title":"Anti-Human CD45\/PTPRC Nanobody (2H7)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003eAntibody against CD45\/PTPRC (Receptor-type tyrosine-protein phosphatase C) for research detection of protein expression and localization.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget biology\u003c\/strong\u003e\u003cbr\u003eCD45 encodes a phosphatase-family protein that counterbalances kinase signaling by dephosphorylating protein substrates. Protein tyrosine phosphatases and dual-specificity phosphatases shape amplitude and duration of signaling pathways such as MAPK and immune receptor signaling, and are frequently investigated in cancer and immunology contexts.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpected localization\u003c\/strong\u003e\u003cbr\u003eMany phosphatases localize to the cytoplasm and\/or nucleus; receptor-type phosphatases are often membrane-associated.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch context\u003c\/strong\u003e\u003cbr\u003eThis target is frequently studied in the context of \u003cem\u003eCell Signaling\u003c\/em\u003e research. Application suitability (e.g., ELISA, SPR) is indicated in the specifications; conditions should be optimized by titration. Species reactivity information is provided in the specifications (reported: Human).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended experimental notes\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\u003cli\u003eFor ELISA, ensure capture\/detection antibody compatibility and run a standard curve; verify sample matrix effects with spike-and-recovery and dilution linearity.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eControls \u0026amp; interpretation\u003c\/strong\u003e\u003cbr\u003eWhere possible, confirm specificity using genetic perturbation (KO\/KD\/CRISPR), peptide competition (if applicable), or an orthogonal readout. Include a negative control sample expected to express low\/none of CD45\/PTPRC, and a positive control sample known to express CD45\/PTPRC.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53036923683181,"sku":"HY195023-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037520978285,"sku":"HY195023-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037521011053,"sku":"HY195023-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HY195023-SDSPAGE-1.jpg?v=1771745866","url":"https:\/\/www.ebiohippo.com\/products\/anti-human-cd45-ptprc-nanobody-2h7-bha21405339","provider":"BioHippo","version":"1.0","type":"link"}