{"product_id":"anti-human-egfr-erbb1-her1-nanobody-7d12-bha21405511","title":"Anti-Human EGFR\/ERBB1\/HER1 Nanobody (7D12)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003eAntibody against EGFR\/ERBB1\/HER1 (Receptor tyrosine-protein kinase erbB-1) for research detection of protein expression and localization.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget biology\u003c\/strong\u003e\u003cbr\u003eEGFR encodes a receptor that transduces extracellular ligand binding into intracellular signaling, shaping cellular activation, differentiation or survival. Receptor expression and localization are frequently assessed in immunology and cancer biology, and receptor engagement often drives rapid phosphorylation and transcriptional responses.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpected localization\u003c\/strong\u003e\u003cbr\u003ePlasma membrane receptor; internalization and endosomal trafficking can occur upon ligand binding or antibody engagement.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch context\u003c\/strong\u003e\u003cbr\u003eThis target is frequently studied in the context of \u003cem\u003eCell Signaling\u003c\/em\u003e research. Application suitability (e.g., ELISA, FUNCS) is indicated in the specifications; conditions should be optimized by titration. Species reactivity information is provided in the specifications (reported: Human).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended experimental notes\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\u003cli\u003eFor ELISA, ensure capture\/detection antibody compatibility and run a standard curve; verify sample matrix effects with spike-and-recovery and dilution linearity.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eControls \u0026amp; interpretation\u003c\/strong\u003e\u003cbr\u003eWhere possible, confirm specificity using genetic perturbation (KO\/KD\/CRISPR), peptide competition (if applicable), or an orthogonal readout. Include a negative control sample expected to express low\/none of EGFR\/ERBB1\/HER1, and a positive control sample known to express EGFR\/ERBB1\/HER1.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53036929515885,"sku":"HF004083-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037532316013,"sku":"HF004083-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037532348781,"sku":"HF004083-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/anti-human-egfr-erbb1-her1-nanobody-7d12-bha21405511","provider":"BioHippo","version":"1.0","type":"link"}