{"product_id":"anti-human-endosialin-cd248-reference-antibody-ontuxizumab-bha21415710","title":"Anti-Human Endosialin\/CD248 Reference Antibody (Ontuxizumab)","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eReference Antibody\u003c\/span\u003e\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cstrong\u003eOntuxizumab\u003c\/strong\u003e (HV681016) is a research-grade recombinant antibody targeting CD164L. Produced in mammalian cells with native-like glycosylation.\n\n\nHighlights\n\u003cul\u003e\n\u003cli\u003e●\u003cstrong\u003eResearch Grade\u003c\/strong\u003e — For PK\/PD studies, assay development, and ADA research.\u003c\/li\u003e\n\u003cli\u003e●\u003cstrong\u003eNative Glycosylation\u003c\/strong\u003e — Mammalian expression ensures native-like patterns.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eHumanized\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG1, kappa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget\u003c\/th\u003e\n\u003ctd\u003eEndosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eProtein A\/G purified from cell culture supernatant.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt;95% purity as determined by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage Buffer\u003c\/th\u003e\n\u003ctd\u003e0.01M PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eExpression System\u003c\/th\u003e\n\u003ctd\u003eMammalian Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt\u003c\/th\u003e\n\u003ctd\u003eQ9HCU0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\u003cth\u003eApplication\u003c\/th\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eELISA\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eFlow Cytometry\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eFunctional Assay\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eIn Vivo Studies\u003c\/td\u003e\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eEndosialin (CD248) is a ~80 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor\/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines.\u003c\/p\u003e\n\u003ch2\u003eReactivity\u003c\/h2\u003e\n\u003cp\u003eThis antibody shows reactivity with Human.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003eFor Research Use Only (RUO). Not for use in diagnostic or therapeutic procedures.\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Biohippo Inc","offers":[{"title":"1 mg","offer_id":53513340354925,"sku":"HV681016-1MG","price":352.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53513504915821,"sku":"HV681016-5MG","price":700.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53513504948589,"sku":"HV681016-10MG","price":1000.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53513504981357,"sku":"HV681016-25MG","price":1800.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53513505014125,"sku":"HV681016-50MG","price":2800.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53513505046893,"sku":"HV681016-100MG","price":4600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HV681016-SDS-PAGE-1.jpg?v=1783375424","url":"https:\/\/www.ebiohippo.com\/products\/anti-human-endosialin-cd248-reference-antibody-ontuxizumab-bha21415710","provider":"BioHippo","version":"1.0","type":"link"}