{"product_id":"anti-human-vegfr1-flt-1-reference-antibody-icrucumab-bha21415531","title":"Anti-Human VEGFR1\/Flt-1 Reference Antibody (Icrucumab)","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eReference Antibody\u003c\/span\u003e\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cstrong\u003eIcrucumab\u003c\/strong\u003e (HB265016) is a research-grade recombinant antibody targeting FLT1. Produced in mammalian cells with native-like glycosylation.\n\n\nHighlights\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch Grade\u003c\/strong\u003e — For PK\/PD studies, assay development, and ADA research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNative Glycosylation\u003c\/strong\u003e — Mammalian expression ensures native-like patterns.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG1, kappa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget\u003c\/th\u003e\n\u003ctd\u003eFLT1, Vascular endothelial growth factor receptor 1, VEGFR1, Vascular permeability factor receptor, FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, FLT, FLT-1, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eProtein A\/G purified from cell culture supernatant.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt;95% purity as determined by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage Buffer\u003c\/th\u003e\n\u003ctd\u003e0.01M PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eExpression System\u003c\/th\u003e\n\u003ctd\u003eMammalian Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt\u003c\/th\u003e\n\u003ctd\u003eP17948\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\u003cth\u003eApplication\u003c\/th\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eELISA\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eFlow Cytometry\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eFunctional Assay\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eIn Vivo Studies\u003c\/td\u003e\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eVascular endothelial growth factor receptor 1 (FLT1\/VEGFR1) is a ~150 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific.\u003c\/p\u003e\n\u003ch2\u003eReactivity\u003c\/h2\u003e\n\u003cp\u003eThis antibody shows reactivity with Human.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003eFor Research Use Only (RUO). Not for use in diagnostic or therapeutic procedures.\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Biohippo Inc","offers":[{"title":"1 mg","offer_id":53513335112045,"sku":"HB265016-1MG","price":352.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53513476145517,"sku":"HB265016-5MG","price":700.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53513476178285,"sku":"HB265016-10MG","price":1000.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53513476211053,"sku":"HB265016-25MG","price":1800.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53513476243821,"sku":"HB265016-50MG","price":2800.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53513476276589,"sku":"HB265016-100MG","price":4600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HB265016-bioactivity-binding-1.jpg?v=1783375271","url":"https:\/\/www.ebiohippo.com\/products\/anti-human-vegfr1-flt-1-reference-antibody-icrucumab-bha21415531","provider":"BioHippo","version":"1.0","type":"link"}