{"product_id":"anti-phospho-chk2-t68-rabbit-monoclonal-antibody-bha21010265","title":"Anti-Phospho-Chk2 (T68) Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-Phospho-Chk2 (T68) Rabbit Monoclonal Antibody catalog # P00277-1. Tested in WB, IP applications. This antibody reacts with Human.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGene\u003c\/strong\u003e: Forkhead box protein O3 | \u003cstrong\u003eTarget\u003c\/strong\u003e: CHEK2 | \u003cstrong\u003eFunction\u003c\/strong\u003e: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Apoptosis,Associated Proteins,Cancer,Cell Biology,Co-Activators\/Co-Repressors,Domain Families,Epigenetics and Nuclear Signaling,Forkhead Box,Hypoxia,Intracellular,Metabolism,Metabolism Processes,Nuclear Receptors,Nuclear Signaling Pathways,Oncoproteins,Oncoproteins\/Suppressors,Pathways and Processes,Transcription,Transcription Factors\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 27C74 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human Phospho-Chk2 (T68) | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB, IP\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 62 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 71277 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Cytoplasm, cytosol. Nucleus. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Ubiquitous. .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePhospho site(s)\u003c\/strong\u003e: T68\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072121037165,"sku":"P00277-1","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/p00277-1-wb.jpg?v=1772621948","url":"https:\/\/www.ebiohippo.com\/products\/anti-phospho-chk2-t68-rabbit-monoclonal-antibody-bha21010265","provider":"BioHippo","version":"1.0","type":"link"}