{"product_id":"anti-phospho-tau-ps396-ps404-antibody-phf1-bha21405630","title":"Anti-Phospho-Tau (pS396\/pS404) Antibody (PHF1)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003eAntibody against Phospho-Tau (pS396\/pS404) (Microtubule-associated protein tau) for research detection of protein expression and localization.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget biology\u003c\/strong\u003e\u003cbr\u003eTau is a microtubule-associated protein that stabilizes microtubules in neurons and supports axonal transport and cytoskeletal organization. Phosphorylation state is tightly regulated; disease-associated hyperphosphorylation and aggregation are central features of tauopathies. This antibody targets a phosphorylation site (pS396\/pS404), often used as a readout of tau modification.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpected localization\u003c\/strong\u003e\u003cbr\u003ePredominantly neuronal cytoskeletal\/axonal; redistribution can occur with stress or pathology.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch context\u003c\/strong\u003e\u003cbr\u003eThis target is frequently studied in the context of \u003cem\u003eNeuroscience\u003c\/em\u003e research. Application suitability (e.g., ELISA) is indicated in the specifications; conditions should be optimized by titration. Species reactivity information is provided in the specifications (reported: Human).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended experimental notes\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\u003cli\u003eFor ELISA, ensure capture\/detection antibody compatibility and run a standard curve; verify sample matrix effects with spike-and-recovery and dilution linearity.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eControls \u0026amp; interpretation\u003c\/strong\u003e\u003cbr\u003eWhere possible, confirm specificity using genetic perturbation (KO\/KD\/CRISPR), peptide competition (if applicable), or an orthogonal readout. Include a negative control sample expected to express low\/none of Phospho-Tau (pS396\/pS404), and a positive control sample known to express Phospho-Tau (pS396\/pS404).\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53036933874029,"sku":"HY086213-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037540671853,"sku":"HY086213-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037540704621,"sku":"HY086213-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HY086213-SDS-PAGE-1.jpg?v=1771746057","url":"https:\/\/www.ebiohippo.com\/products\/anti-phospho-tau-ps396-ps404-antibody-phf1-bha21405630","provider":"BioHippo","version":"1.0","type":"link"}