{"product_id":"anti-plcb1-rabbit-monoclonal-antibody-bha21010344","title":"Anti-PLCB1 Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-PLCB1 Rabbit Monoclonal Antibody catalog # M02817. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein\u003c\/strong\u003e: T-cell surface glycoprotein CD3 zeta chain | \u003cstrong\u003eGene\u003c\/strong\u003e: Mitogen-activated protein kinase 7 | \u003cstrong\u003eTarget\u003c\/strong\u003e: PLCB1 | \u003cstrong\u003eFunction\u003c\/strong\u003e: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1\/ERK1 or MEK2\/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53\/TP53 by disrupting the PML-MDM2 interaction. . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Intracellular Signaling,Kinases,MAPK Pathway,Neural Signal Transduction,Neurology Process,Neuroscience,Neurotransmission,Protein Phosphorylation,Ser\/Thr Kinases,Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 28P54 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human,Mouse,Rat | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human PLCB1 | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB, IHC\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 100 kDa,150 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 88386 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072124543341,"sku":"M02817","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/blank_44552639-bf17-481c-9416-bb6d93afd0c0.png?v=1772695657","url":"https:\/\/www.ebiohippo.com\/products\/anti-plcb1-rabbit-monoclonal-antibody-bha21010344","provider":"BioHippo","version":"1.0","type":"link"}