{"product_id":"anti-ptpn2-rabbit-monoclonal-antibody-bha21010257","title":"Anti-PTPN2 Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-PTPN2 Rabbit Monoclonal Antibody catalog # M01597. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein\u003c\/strong\u003e: Lysosome-associated membrane glycoprotein 2 (Lamp2) | \u003cstrong\u003eGene\u003c\/strong\u003e: E3 ubiquitin-protein ligase NEDD4-like | \u003cstrong\u003eTarget\u003c\/strong\u003e: PTPN2 | \u003cstrong\u003eFunction\u003c\/strong\u003e: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Cell Biology,Chromatin Modifying Enzymes,Epigenetics and Nuclear Signaling,Proteasome \/ Ubiquitin,Proteolysis\/Ubiquitin,Ubiquitin E3 Enzymes\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 27P66 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human,Mouse | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human PTPN2 | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB, ICC, FC, IP\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 40-48 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 111932 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Cytoplasm . May be recruited to exosomes by NDFIP1.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003). .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072119791981,"sku":"M01597","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/m01597-wb.jpg?v=1772621946","url":"https:\/\/www.ebiohippo.com\/products\/anti-ptpn2-rabbit-monoclonal-antibody-bha21010257","provider":"BioHippo","version":"1.0","type":"link"}