{"product_id":"anti-safb-rabbit-monoclonal-antibody-bha21010499","title":"Anti-SAFB Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-SAFB Rabbit Monoclonal Antibody catalog # M03458-1. Tested in WB, IHC, ICC\/IF applications. This antibody reacts with Human, Mouse, Rat.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein\u003c\/strong\u003e: T-cell surface glycoprotein CD3 zeta chain | \u003cstrong\u003eGene\u003c\/strong\u003e: E3 ubiquitin-protein ligase BRE1A | \u003cstrong\u003eTarget\u003c\/strong\u003e: SAFB | \u003cstrong\u003eFunction\u003c\/strong\u003e: Component of the RNF20\/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20\/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1\/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53\/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Cell Biology,Chromatin Modifying Enzymes,Epigenetics and Nuclear Signaling,Histones,Proteasome \/ Ubiquitin,Proteolysis\/Ubiquitin,Ring Finger E3 Ligase,Ubiquitin E3 Enzymes\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 30S09 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human,Mouse,Rat | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human SAFB | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB, IHC, IF, ICC\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 150 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 113662 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Nucleus .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Expressed in the normal brain and also in malignant gliomas (at protein level). .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072130474349,"sku":"M03458-1","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/m03458-1-wb.jpg?v=1772621971","url":"https:\/\/www.ebiohippo.com\/products\/anti-safb-rabbit-monoclonal-antibody-bha21010499","provider":"BioHippo","version":"1.0","type":"link"}