{"product_id":"anti-ssx2ip-rabbit-monoclonal-antibody-bha21010555","title":"Anti-SSX2IP Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-SSX2IP Rabbit Monoclonal Antibody catalog # M05918-1. Tested in WB, IHC applications. This antibody reacts with Human.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein\u003c\/strong\u003e: T-cell surface glycoprotein CD3 zeta chain | \u003cstrong\u003eGene\u003c\/strong\u003e: Golgin subfamily A member 2 | \u003cstrong\u003eTarget\u003c\/strong\u003e: SSX2IP | \u003cstrong\u003eFunction\u003c\/strong\u003e: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115\/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115\/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin- alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Metabolic Signaling Pathways,Metabolism,Pathways and Processes,Signal Transduction,Cancer,Cell Biology,Energy Transfer Pathways,Cancer Metabolism,Metabolic Signaling Pathway,Oxidative Stress,Redox Metabolism,Mitochondrial Metabolism,Mitochondrial,Mitochondrial Markers,Integration Of Energy,Integration Of Energy Metabolism,Oxidative Phosphorylation\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 30S65 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human SSX2IP | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB, IHC\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 74,76 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 113086 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, spindle pole . Peripheral membrane protein associated with cis-Golgi stacks (By similarity). Associates with the mitotic spindle during mitosis (PubMed:26165940). .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Expressed in all tissues examined.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072131850605,"sku":"M05918-1","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/m05918-1-wb.jpg?v=1772621982","url":"https:\/\/www.ebiohippo.com\/products\/anti-ssx2ip-rabbit-monoclonal-antibody-bha21010555","provider":"BioHippo","version":"1.0","type":"link"}