{"product_id":"anti-toe1-rabbit-monoclonal-antibody-bha21010290","title":"Anti-TOE1 Rabbit Monoclonal Antibody","description":"\u003cp\u003eBoster Bio Anti-TOE1 Rabbit Monoclonal Antibody catalog # M09852. Tested in WB application. This antibody reacts with Human.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein\u003c\/strong\u003e: T-cell surface glycoprotein CD3 zeta chain | \u003cstrong\u003eGene\u003c\/strong\u003e: Cysteine protease ATG4C | \u003cstrong\u003eTarget\u003c\/strong\u003e: TOE1 | \u003cstrong\u003eFunction\u003c\/strong\u003e: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. . | \u003cstrong\u003eResearch areas\u003c\/strong\u003e: Metabolism Processes,Oncoproteins,Oncoproteins\/Suppressors,Pathways and Processes,Proteolysis\/Ubiquitin,Proteolytic Enzymes,Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Monoclonal \/ Clone: 27T99 | \u003cstrong\u003eIsotype\u003c\/strong\u003e: IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Human | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: A synthesized peptide derived from human TOE1 | \u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5mg\/ml | \u003cstrong\u003ePurification\u003c\/strong\u003e: Affinity-chromatography\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 60 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 52497 MW\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCellular localization\u003c\/strong\u003e: Cytoplasm .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTissue details\u003c\/strong\u003e: Highly expressed in skeletal muscle, heart, liver and testis. .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 uL\/vial \/ Unconjugated","offer_id":53072122315117,"sku":"M09852","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/m09852-wb.jpg?v=1772621948","url":"https:\/\/www.ebiohippo.com\/products\/anti-toe1-rabbit-monoclonal-antibody-bha21010290","provider":"BioHippo","version":"1.0","type":"link"}