{"product_id":"anti-zebrafish-mypt1-ppp1r12a-antibody-picoband-bha21012408","title":"Anti-Zebrafish MYPT1\/PPP1R12A Antibody Picoband®","description":"\u003cp\u003eBoster Bio Anti-Zebrafish MYPT1\/PPP1R12A Antibody Picoband® catalog # AZQ6DRG7. Tested in WB, IHC applications. This antibody reacts with Zebrafish. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eScientific background\u003c\/strong\u003e: PPP1R12A (Protein phosphatase 1 regulatory subunit 12A), also called MYPT1 (Myosin phosphatase target subunit 1), is an enzyme that in humans is encoded by the PPP1R12A gene. PPP1R12A is one of the subunits of myosin phosphatase. Sequencing analysis showed that human PPP1R12A contains 1,030 amino acids with a calculated molecular mass of approximately 115 kD. The PPP1R12A gene is mapped on 12q21.2-q21.3. PPP1R12A is the protein that regulates PP1 function in smooth muscle relaxation. The cellular MYPT1-PP1-delta -specific inhibitor CPI17 caused a loss of merlin function characterized by merlin phosphorylation, Ras activation, and transformation. Jin et al. concluded that PPP1R12A and its substrate merlin are part of a previously undescribed tumor suppressor cascade that can be hindered in two ways, by mutation of the NF2 gene and by upregulation of the oncoprotein CPI17.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget\u003c\/strong\u003e: PPP1R12A\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e: Rabbit | \u003cstrong\u003eClonality\/Clone\u003c\/strong\u003e: Polyclonal | \u003cstrong\u003eIsotype\u003c\/strong\u003e: Rabbit IgG | \u003cstrong\u003eReactivity\u003c\/strong\u003e: Zebrafish | \u003cstrong\u003eImmunogen\u003c\/strong\u003e: E.coli-derived zebrafish MYPT1\/PPP1R12A recombinant protein (Position: M1-D40). | \u003cstrong\u003eConcentration\u003c\/strong\u003e: Adding 0.2 ml of distilled water will yield a concentration of 500 μg\/ml. | \u003cstrong\u003ePurification\u003c\/strong\u003e: Immunogen affinity purified.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e: WB, IHC\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e: 140 kDa | \u003cstrong\u003eCalculated MW\u003c\/strong\u003e: 115 kDa\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e: Active\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"100 ug\/vial \/ Unconjugated","offer_id":53072180052333,"sku":"AZQ6DRG7","price":470.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Biotin","offer_id":53072585785709,"sku":"AZQ6DRG7-Biotin","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Cy3","offer_id":53072585818477,"sku":"AZQ6DRG7-Cy3","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Fluoro488","offer_id":53072585851245,"sku":"AZQ6DRG7-Fluoro488","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Fluoro550","offer_id":53072585884013,"sku":"AZQ6DRG7-Fluoro550","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Fluoro594","offer_id":53072585916781,"sku":"AZQ6DRG7-Fluoro594","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ FITC","offer_id":53072585949549,"sku":"AZQ6DRG7-FITC","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ HRP","offer_id":53072585982317,"sku":"AZQ6DRG7-HRP","price":670.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ APC","offer_id":53072586015085,"sku":"AZQ6DRG7-APC","price":920.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ PE","offer_id":53072586047853,"sku":"AZQ6DRG7-PE","price":920.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Fluoro647","offer_id":53072586080621,"sku":"AZQ6DRG7-Fluoro647","price":770.0,"currency_code":"USD","in_stock":true},{"title":"100 ug\/vial \/ Carrier Free","offer_id":53072586113389,"sku":"AZQ6DRG7-carrier-free","price":470.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/azq6drg7-ppp1r12a-primary-antibodies-wb-testing-1.jpg?v=1772695830","url":"https:\/\/www.ebiohippo.com\/products\/anti-zebrafish-mypt1-ppp1r12a-antibody-picoband-bha21012408","provider":"BioHippo","version":"1.0","type":"link"}