{"product_id":"ap-18-bhb21300011","title":"AP-18","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 55224-94-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C11H12ClNO.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-100 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPA1 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e AP-18 has an IC50 of 3.1 and 4.5 μM for human and mouse TRPA1, respectively1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eThe transient receptor potential (TRP) channel is one of the largest families of cation channels1. TRPA1 is expressed in sensory and nociceptive neurons and has a significant role in inflammatory responses. Bradykinin and histamine receptors induce TRPA1 activity. A study conducted found that TRPA1 deficient mice did not develop an elevated mechanical and thermal pain response following bradykinin injection, suggesting that TRPA1 has a vital role in bradykinin signaling pathways2.TRPA1 also plays a role in acute and chronic respiratory disease pathophysiology. Prolonged exposure to TRPA1 agonists such as chlorine and aldehydes can cause reactive airways dysfunction syndrome characterized by symptoms such as wheezing, coughing and dyspnea. In light of this, TRPA1 may be a target for airway anti-inflammatory research3.AP-18 is a reversible TRPA1 blocker with an IC50 value of 3.1 and 4.5 μM for human and rat TRPA1 channels respectively.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249706295661,"sku":"A-250-10MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311546687853,"sku":"A-250-25MG-1","price":184.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311546720621,"sku":"A-250-5MG-1","price":66.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311546753389,"sku":"A-250-50MG-1","price":337.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-250_str-1.gif?v=1778544408","url":"https:\/\/www.ebiohippo.com\/products\/ap-18-bhb21300011","provider":"BioHippo","version":"1.0","type":"link"}