{"product_id":"aquaporin-4-antibody-bha11907938","title":"Aquaporin 4 Antibody","description":"\u003cp\u003eAquaporin 4 (AQP4) is a key water channel protein predominantly expressed in the central nervous system, where it plays a critical role in maintaining brain water balance. While it is also found in the basolateral membrane of renal collecting duct cells, its most significant physiological and pathological functions are observed in the brain, particularly in astrocyte endfeet at the blood-brain barrier and around brain ventricles.\u003c\/p\u003e\n\n\u003cp\u003eAQP4 facilitates bidirectional water transport in response to osmotic gradients, contributing to cerebrospinal fluid dynamics, neurovascular coupling, and the clearance of metabolic waste via the glymphatic system. Its expression is rapidly upregulated in response to central nervous system (CNS) injury, including trauma, ischemia, and neuroinflammation, making it a key player in the development of cerebral edema and gliosis.\u003c\/p\u003e\n\n\u003cp\u003eImportantly, AQP4 is the primary autoimmune target in neuromyelitis optica spectrum disorder (NMOSD), a severe inflammatory demyelinating disease of the CNS. Autoantibodies against AQP4 (AQP4-IgG) lead to astrocyte damage, blood-brain barrier disruption, and secondary neuronal injury.\u003c\/p\u003e\n\n\u003cp\u003eBeyond NMOSD, dysregulation of AQP4 has been implicated in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, where impaired water clearance and neuroinflammation contribute to disease progression. As such, AQP4 is increasingly recognized as a promising biomarker and therapeutic target in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040794829165,"sku":"SPC-505D","price":337.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040880648557,"sku":"SPC-505D-A390","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040880681325,"sku":"SPC-505D-A488","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040880714093,"sku":"SPC-505D-A594","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040880746861,"sku":"SPC-505D-APC","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040880779629,"sku":"SPC-505D-BI","price":386.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040880812397,"sku":"SPC-505D-FITC","price":381.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040880845165,"sku":"SPC-505D-HRP","price":377.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040880877933,"sku":"SPC-505D-PCP","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040880910701,"sku":"SPC-505D-RPE","price":388.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040880943469,"sku":"SPC-505S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-505_Aquaporin-4_Antibody_IHC_Rat_kidney-tissue_1.png?v=1771832158","url":"https:\/\/www.ebiohippo.com\/products\/aquaporin-4-antibody-bha11907938","provider":"BioHippo","version":"1.0","type":"link"}