{"product_id":"arecaidine-propargyl-ester-hydrobromide-bhb21900900","title":"Arecaidine propargyl ester hydrobromide","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eAgonists\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003eArecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors that inhibits tumor cell proliferation. In vitro, it can reduce the number of ovarian cancer cells and induce apoptosis and reactive oxygen species (ROS) production at specific concentrations, and it can also arrest cells at the G2\/M phase of the cell cycle while increasing the percentage of abnormal mitosis. It sensitizes ovarian surface epithelial cells with higher M2 receptor levels more than it does cancer cells, and under natural physiological conditions it lowers arterial blood pressure through its interaction with the cardiovascular system, indicating potential pharmacological application\u003csup\u003e[1]\u003c\/sup\u003e. It is supplied as a white to off-white solid (C10H14BrNO2, MW 260.13) at 99.47% purity.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e116511-28-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC10H14BrNO2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e260.13 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e99.47%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAppearance\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eColor\u003c\/th\u003e\n\u003ctd\u003eWhite to off-white\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd\u003eO=C(C1=CCCN(C1)C)OCC#C.Br\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003eApoptosis; Cell Cycle\/DNA Damage\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSolubility\u003c\/th\u003e\n\u003ctd\u003eIn Vitro: DMSO: 100 mg\/mL (384.42 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35775813\/\"\u003eThe activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"5 mg","offer_id":67604884095341,"sku":"HY-134061-5MG","price":74.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":67605158134125,"sku":"HY-134061-10MG","price":111.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":67605158166893,"sku":"HY-134061-25MG","price":198.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":67605158199661,"sku":"HY-134061-50MG","price":306.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":67605158232429,"sku":"HY-134061-100MG","price":476.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":67605158265197,"sku":"HY-134061-250MG","price":807.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":67605158297965,"sku":"HY-134061-500MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":67605158330733,"sku":"HY-134061-1G","price":0.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":67605158363501,"sku":"HY-134061-1MLX10MM","price":81.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hy-134061.gif?v=1790972945","url":"https:\/\/www.ebiohippo.com\/products\/arecaidine-propargyl-ester-hydrobromide-bhb21900900","provider":"BioHippo","version":"1.0","type":"link"}